METAL-ION COORDINATION IN THE DNA-BINDING DOMAIN OF THE YEAST TRANSCRIPTIONAL ACTIVATOR GAL4

被引：28

作者：

POVEY, JF

DIAKUN, GP

GARNER, CD

WILSON, SP

LAUE, ED

机构：

[1] DEPT BIOCHEM,TENNIS COURT RD,CAMBRIDGE CB2 1QW,ENGLAND

[2] SERC,DARESBURY LAB,MRC,BIOL SUPPORT LAB,WARRINGTON WA4 4AD,CHESHIRE,ENGLAND

[3] UNIV MANCHESTER,DEPT CHEM,MANCHESTER M13 9PL,LANCS,ENGLAND

来源：

FEBS LETTERS | 1990年 / 266卷 / 1-2期

关键词：

DNA binding; Extended X-ray fine structure; GAL4; Saccharomyces cerevisiae; Structure; Zinc finger;

D O I：

10.1016/0014-5793(90)81525-S

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the DNA binding domain of the yeast transcriptional activator GAL4 was investigated by extended X-ray fine structure (e.x.a.f.s.). Two samples of GAL4 were studied, one containing cadmium as a structural probe (Cd(II)GAL4) and the other containing the 'native' zinc (Zn(Il)-GAL4). The results suggest that the structure of the DNA binding domain of GAL4 contains a two metal ion cluster distinguishing it from the 'zinc finger' proteins typified by the Xenopus laevis transcription factor TFIIIA. © 1990.

引用

页码：142 / 146

页数：5

共 19 条

[1] STRUCTURAL STUDY OF THE COPPER AND ZINC SITES IN METALLOTHIONEINS BY USING EXTENDED X-RAY-ABSORPTION FINE-STRUCTURE
ABRAHAMS, IL
BREMNER, I
DIAKUN, GP
GARNER, CD
HASNAIN, SS
ROSS, I
VASAK, M
[J]. BIOCHEMICAL JOURNAL, 1986, 236 (02) : 585 - 589
[2] NATURE OF THE CADMIUM SITES IN RAT-LIVER METALLOTHIONEIN-1 FROM CD K-EDGE EXAFS
ABRAHAMS, IL
GARNER, CD
BREMNER, I
DIAKUN, GP
HASNAIN, SS
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1985, 107 (15) : 4596 - 4597
[3] AN AMINO-TERMINAL FRAGMENT OF GAL4 BINDS DNA AS A DIMER
CAREY, M
KAKIDANI, H
LEATHERWOOD, J
MOSTASHARI, F
PTASHNE, M
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1989, 209 (03) : 423 - 432
[4] A 13-ELEMENT GE DETECTOR FOR FLUORESCENCE EXAFS
CRAMER, SP
TENCH, O
YOCUM, M
GEORGE, GN
[J]. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT, 1988, 266 (1-3) : 586 - 591
[5] TAT PROTEIN FROM HUMAN IMMUNODEFICIENCY VIRUS FORMS A METAL-LINKED DIMER
FRANKEL, AD
BREDT, DS
PABO, CO
[J]. SCIENCE, 1988, 240 (4848) : 70 - 73
[6] THE FUNCTION AND STRUCTURE OF THE METAL COORDINATION SITES WITHIN THE GLUCOCORTICOID RECEPTOR DNA-BINDING DOMAIN
FREEDMAN, LP
LUISI, BF
KORSZUN, ZR
BASAVAPPA, R
SIGLER, PB
YAMAMOTO, KR
[J]. NATURE, 1988, 334 (6182) : 543 - 546
[7] EQUILIBRIA AND KINETICS OF LAC REPRESSOR-OPERATOR INTERACTIONS BY POLYACRYLAMIDE-GEL ELECTROPHORESIS
FRIED, M
CROTHERS, DM
[J]. NUCLEIC ACIDS RESEARCH, 1981, 9 (23) : 6505 - 6525
[8] SPECIFIC DNA-BINDING OF GAL4, A POSITIVE REGULATORY PROTEIN OF YEAST
GINIGER, E
VARNUM, SM
PTASHNE, M
[J]. CELL, 1985, 40 (04) : 767 - 774
[9] A RAPID, EXACT CURVED-WAVE THEORY FOR EXAFS CALCULATIONS
GURMAN, SJ
BINSTED, N
ROSS, I
[J]. JOURNAL OF PHYSICS C-SOLID STATE PHYSICS, 1984, 17 (01): : 143 - 151
[10] GENETIC-EVIDENCE THAT ZINC IS AN ESSENTIAL COFACTOR IN THE DNA-BINDING DOMAIN OF GAL4 PROTEIN
JOHNSTON, M
[J]. NATURE, 1987, 328 (6128) : 353 - 355

← 1 2 →