CEREBROVASCULAR AND FUNCTIONAL CONSEQUENCES OF 5-HT1A RECEPTOR ACTIVATION

被引：26

作者：

MCBEAN, DE ^{[1
]}

SHARKEY, J ^{[1
]}

RITCHIE, IM ^{[1
]}

KELLY, PAT ^{[1
]}

机构：

[1] UNIV EDINBURGH,WESTERN GEN HOSP,DEPT CLIN NEUROSCI,CREWE RD S,EDINBURGH EH4 2XU,MIDLOTHIAN,SCOTLAND

来源：

BRAIN RESEARCH | 1991年 / 555卷 / 01期

基金：

英国惠康基金;

关键词：

LOCAL CEREBRAL BLOOD FLOW; LOCAL CEREBRAL GLUCOSE UTILIZATION; 8-HYDROXY-2-(DI-NORMAL-PROPYLAMINO)TETRALIN; FLOW-METABOLISM COUPLING;

D O I：

10.1016/0006-8993(91)90873-T

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cerebral glucose utilization and blood flow were measured in rats using 2-deoxy-D-[C-14]glucose and [C-14]iodoantipyrine quantitative autoradiography, respectively, following treatment with the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT). In control and 8-OH-DPAT-treated animals blood flow and glucose use were similarly correlated, but the ratio was increased following 8-OH-DPAT treatment. Since 5-HT1A receptor activation is known to reduce neuronal 5-HT release, these results are consistent with a vasoconstrictor role for endogenous serotonin.

引用

页码：159 / 163

页数：5

共 36 条

[1]

AGHAJANIAN GK, 1978, ESSAYS NEUROCHEMISTR, P1

[2]

EDVINSSON L, 1977, BLOOD VESSELS, V14, P366

[3] IDENTITY OF INHIBITORY PRESYNAPTIC 5-HYDROXYTRYPTAMINE (5-HT) AUTORECEPTORS IN THE RAT-BRAIN CORTEX WITH 5-HT1B BINDING-SITES [J].