MOLECULAR-CLONING AND DEVELOPMENTAL EXPRESSION OF HUMAN CARDIAC TROPONIN-T

被引：64

作者：

MESNARD, L

SAMSON, F

ESPINASSE, I

DURAND, J

NEVEUX, JY

MERCADIER, JJ

机构：

[1] University of Paris XI, CNRS URA 1159, Hôpital Marie Lannelongue, Le Plessis Robinson

来源：

FEBS LETTERS | 1993年 / 328卷 / 1-2期

关键词：

TROPONIN-T; HUMAN HEART; CARDIAC MUSCLE; SKELETAL MUSCLE; DEVELOPMENT;

D O I：

10.1016/0014-5793(93)80981-Y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have isolated a full-size cDNA coding for cardiac troponin T (cTnT) from a human adult heart library, using a slow skeletal TnT probe. This cDNA detected a 1.2 kb mRNA in fetal and post-natal human heart, the amount of which increased during ontogenic development. Interestingly, a similar transcript was coexpressed in fetal skeletal muscle, together with the 0.9 kb slow skeletal muscle mRNA, and its expression was down-regulated during further development.

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页码：139 / 144

页数：6

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