DSP-4, A NORADRENERGIC NEUROTOXIN, PRODUCES MORE SEVERE BIOCHEMICAL AND FUNCTIONAL DEFICITS IN AGED THAN YOUNG-RATS

被引：24

作者：

RIEKKINEN, P ^{[1
]}

RIEKKINEN, M ^{[1
]}

VALJAKKA, A ^{[1
]}

RIEKKINEN, P ^{[1
]}

SIRVIO, J ^{[1
]}

机构：

[1] UNIV KUOPIO,DEPT PATHOL,SF-70211 KUOPIO,FINLAND

来源：

BRAIN RESEARCH | 1992年 / 570卷 / 1-2期

关键词：

LESION; NORADRENALINE; DOPAMINE; SEROTONIN; CHOLINE ACETYLTRANSFERASE; HIGH-VOLTAGE SPINDLE; YOUNG VS AGED RAT;

D O I：

10.1016/0006-8993(92)90593-X

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study examines the effects of noradrenergic lesions (either DSP-4 i.p. or 6-hydroxydopamine (6-OHDA) into the dorsal noradrenergic bundle on biochemical (noradrenaline (NA), dopamine (DA), serotonin (5-HT) and choline acetyltransferase (ChAT) activity) and cortical EEG (quantitative EEG (qEEG) and high-voltage spindle (HVS)) activity in young and aged rats. Near complete 6-OHDA NA lesions, but not partial DSP-4 NA lesions, increased HVS activity in young rats. DSP-4 and 6-OHDA lesions produced no significant changes in the 5-HT or DA levels or in the ChAT activity in young rats. In some of the aged rats, DSP-4 produced similar biochemical and HVS effects, as it induced in young rats. In the remainder of the aged rats, NA levels were greatly and 5-HT levels slightly decreased. DA levels and ChAT activity were unaltered in either set of aged rats. HVS activity was increased only in that group of aged rats with the greatly lowered NA content. These results suggest that: (1) some of the aged rats are more sensitive to DSP-4 treatment than young adult rats; and (2) NA depletions have to be complete to produce an increase in HVS activity in young and aged rats.

引用

页码：293 / 299

页数：7

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