BRIEF REPORT - PRIMARY INFECTION WITH ZIDOVUDINE-RESISTANT HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

被引：220

作者：

ERICE, A

MAYERS, DL

STRIKE, DG

SANNERUD, KJ

MCCUTCHAN, FE

HENRY, K

BALFOUR, HH

机构：

[1] UNIV MINNESOTA,SCH MED,DEPT LAB MED & PATHOL,MINNEAPOLIS,MN 55455

[2] UNIV MINNESOTA,SCH MED,DEPT MED,MINNEAPOLIS,MN 55455

[3] UNIV MINNESOTA,SCH MED,DEPT PEDIAT,MINNEAPOLIS,MN 55455

[4] AIDS CLIN TRIALS UNIT,MINNEAPOLIS,MN

[5] WALTER REED ARMY INST RES,USN,MED RES INST,WASHINGTON,DC 20307

[6] WALTER REED ARMY INST RES,DIV RETROVIROL,WASHINGTON,DC 20307

[7] HENRY M JACKSON FDN RES LAB,ROCKVILLE,MD

[8] GRP HLTH INC,RIVERSIDE MED CTR,MINNEAPOLIS,MN

[9] ST PAUL RAMSEY MED CTR,ST PAUL,MN 55101

来源：

NEW ENGLAND JOURNAL OF MEDICINE | 1993年 / 328卷 / 16期

关键词：

D O I：

10.1056/NEJM199304223281605

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Strains of human immunodeficiency virus type 1 (HIV-1) with reduced sensitivity to zidovudine have been isolated from patients treated with this drug for six months or more1. Resistance to zidovudine is associated with late-stage disease, low CD4 lymphocyte counts, longer antiretroviral therapy, and specific mutations in the reverse transcriptase gene of HIV-12,3. The clinical importance of infections with resistant HIV-1 isolates is not well understood. We describe a patient with symptomatic HIV-1 infection who had primary infection with a virus resistant to zidovudine, according to both phenotypic and genotypic analyses. Case Report The patient was a 20-year-old… © 1993, Massachusetts Medical Society. All rights reserved.

引用

页码：1163 / 1165

页数：3

共 20 条

[1] ORDERED APPEARANCE OF ZIDOVUDINE RESISTANCE MUTATIONS DURING TREATMENT OF 18 HUMAN IMMUNODEFICIENCY VIRUS-POSITIVE SUBJECTS [J].