CYTOTOXIC ALKALOIDS FROM THE FLATWORM PROSTHECERAEUS-VILLATUS AND ITS TUNICATE PREY CLAVELINA-LEPADIFORMIS

被引：86

作者：

KUBANEK, J

WILLIAMS, DE

DESILVA, ED

ALLEN, T

ANDERSEN, RJ

机构：

[1] UNIV BRITISH COLUMBIA,DEPT CHEM & OCEANOG,VANCOUVER,BC V6T 1Z4,CANADA

[2] UNIV ALBERTA,DEPT PHARMACOL,EDMONTON,AB T6G 2H7,CANADA

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 35期

关键词：

D O I：

10.1016/0040-4039(95)01246-E

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Four novel alkaloids, lepadins B (2) and C (3) and villatamines A (4) and B (5), have been isolated from the predatory flatworm Prostheceraeus villatus and its tunicate prey Clavelina lepadiformis. Lepadins A (1) and B (2) and villatamine B (5) exhibit significant in vitro cytotoxicity against human cancer cell lines.

引用

页码：6189 / 6192

页数：4