PROFILES OF EMETIC ACTION OF CISPLATIN IN THE FERRET - A POTENTIAL MODEL OF ACUTE AND DELAYED EMESIS

被引：52

作者：

RUDD, JA ^{[1
]}

JORDAN, CC ^{[1
]}

NAYLOR, RJ ^{[1
]}

机构：

[1] GLAXO GRP RES LTD,RES & DEV,WARE SG12 0DP,HERTS,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1994年 / 262卷 / 1-2期

关键词：

EMESIS; ACUTE; DELAYED; CISPLATIN;

D O I：

10.1016/0014-2999(94)90048-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The emetic profile of action of cisplatin 5 and 10 mg/kg i.p. was investigated in the ferret over a 72 and 40 h period respectively. Cisplatin 10 mg/kg induced retching and vomiting which rapidly declined after the first 8 h. Cisplatin 5 mg/kg induced a less intense emetic response which declined after 16 h but reappeared at approximately 32 h to reveal a 'delayed' retching and vomiting response. The use of cisplatin 5 mg/kg may offer a regimen to model cytotoxic acute and delayed emesis.

引用

页码：R1 / R2

页数：2