INVERSION OF ENANTIOSELECTIVITY IN HYDROLYSIS OF 1,4-DIHYDROPYRIDINES BY POINT MUTATION OF LIPASE PS

被引：55

作者：

HIROSE, Y ^{[1
]}

KARIYA, K ^{[1
]}

NAKANISHI, Y ^{[1
]}

KURONO, Y ^{[1
]}

ACHIWA, K ^{[1
]}

机构：

[1] UNIV SHIZUOKA,SCH PHARMACEUT SCI,SHIZUOKA 422,JAPAN

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 07期

关键词：

D O I：

10.1016/0040-4039(94)02454-J

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Mutant of lipase PS replaced three amino acids by site-specific mutagenesis first showed the inversion of enantioselectivity and the solvent effect in hydrolysis of 1,4-dihydropyridines.

引用

页码：1063 / 1066

页数：4

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