NEW CYTOTOXIC STEROIDS FROM THE MARINE SPONGE DYSIDEA-FRAGILIS COMING FROM THE LAGOON OF VENICE

被引：36

作者：

AIELLO, A

FATTORUSSO, E

MENNA, M

CARNUCCIO, R

IUVONE, T

机构：

[1] DIPARTIMENTO CHIM SOSTANZE NAT,NAPLES,ITALY

[2] DIPARTIMENTO FARMACOL SPERIMENTALE,NAPLES,ITALY

来源：

STEROIDS | 1995年 / 60卷 / 10期

关键词：

DICTYOCERATIDA; DYSIDEA FRAGILIS; POLYHYDROXYSTEROIDS; SULFATE STEROIDS; NMR SPECTRA; CYTOTOXIC ACTIVITY;

D O I：

10.1016/0039-128X(95)00055-U

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The sterol composition of the sponge Dysidea fragilis, coming from the lagoon of venice, has been investigated; our results confirmed the variability of D. fragilis biochemistry. The sponge elaborates, in addition to eight usual 3 beta-hydroxy sterols, thirteen polyhydroxysterols, eight of them (6-13) were novel compounds. Their structures weve established by spectroscopic data. New compounds 3 beta,5 alpha,6 beta,7 alpha-tetrahydroxy-cholest-8(9)-en-11-one (8), 3 beta,5 alpha,6 alpha-trihydroxy-9,11-secocholest-7-en-9-one (9) and 3 beta,5 alpha,6 alpha,9 alpha-tetrahydroxy-cholest-7-ene-6-sulfate (11) were proved to be cytotoxic on two different tumor cell lines in vitro.

引用

页码：666 / 673

页数：8

共 21 条

[1] C-13 NMR-STUDIES .69. C-13 NMR-SPECTRA OF STEROIDS - SURVEY AND COMMENTARY
BLUNT, JW
STOTHERS, JB
[J]. ORGANIC MAGNETIC RESONANCE, 1977, 9 (08): : 439 - 464
[2] BORTOLOTTO M, 1976, B SOC CHIM BELG, V85, P27
[3] BREITMAIER E, 1990, CARBON 13 NMR SPECTR, P209
[4] FUJIMOTO Y, 1985, CHEM PHARM BULL, V33, P3129
[5] PENLANFURAN, A NEW FURANOID SESQUITERPENE FROM THE MARINE SPONGE DYSIDEA-FRAGILIS (MONT) OF BRITTANY - A STRIKING DIFFERENCE WITH THE SAME HAWAIIAN SPECIES
GUELLA, G
GUERRIERO, A
TRALDI, P
PIETRA, F
[J]. TETRAHEDRON LETTERS, 1983, 24 (36) : 3897 - 3898
[6] SESQUITERPENOIDS OF THE SPONGE DYSIDEA-FRAGILIS OF THE NORTH-BRITTANY SEA
GUELLA, G
GUERRIERO, A
PIETRA, F
[J]. HELVETICA CHIMICA ACTA, 1985, 68 (01) : 39 - 48
[7] GUNASEKAR SP, 1985, J ORG CHEM, V48, P885
[8] HEGGERT H, 1976, J ORG CHEM, V41, P71
[9] NEW ANTIPROLIFERATIVE 9,11-SECOSTEROL FROM SOFT CORAL GERSEMIA-FRUTICOSA
KOLJAK, R
PEHK, T
JARVING, I
LIIV, M
LOPP, A
VARVAS, K
VAHEMETS, A
SAMEL, N
LILLE, U
[J]. TETRAHEDRON LETTERS, 1993, 34 (12) : 1985 - 1986
[10] NEW TETRAHYDROXYLATED STEROLS FROM THE MARINE SPONGE SPONGIA-OFFICINALIS
MIGLIUOLO, A
NOTARO, G
PICCIALLI, V
SICA, D
[J]. JOURNAL OF NATURAL PRODUCTS, 1990, 53 (06): : 1414 - 1424

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