INHIBITION OF HERPES-SIMPLEX VIRUS-INFECTION BY NEGATIVELY CHARGED AND NEUTRAL CARBOHYDRATE POLYMERS

被引：40

作者：

MARCHETTI, M ^{[1
]}

PISANI, S ^{[1
]}

PIETROPAOLO, V ^{[1
]}

SEGANTI, L ^{[1
]}

NICOLETTI, R ^{[1
]}

ORSI, N ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,FONDAZ CENCI BOLOGNETTI,IST PASTEUR,IST MICROBIOL,I-00185 ROME,ITALY

来源：

JOURNAL OF CHEMOTHERAPY | 1995年 / 7卷 / 02期

关键词：

POLYSACCHARIDES; ANTIVIRAL AGENTS; HSV;

D O I：

10.1179/joc.1995.7.2.90

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Different natural and semisynthetic polysaccharides were evaluated for their inhibitory effect on in vitro replication of herpes simplex virus (HSV) types 1 and 2. Some neutral and negatively charged carbohydrates were able to inhibit viral infection by interfering mainly with the adsorption process showing a dose-dependent relationship, Their effect was shown within the concentration range of 200-0.8 mu g/ml, and the inhibiting compounds were in order of action: dextran sulfate = scleroglucan = lambda carrageenan > glyloid sulfate 4324 > locust bean gum towards HSV-1 and dextran sulfate = glyloid sulfate 4324 = lambda carrageenan > scleroglucan > glycogen sulfate 4435 towards HSV-2. The data obtained indicate that the antiviral activity of polysaccharides was not only related to their electric charge. Other characteristics of the molecules such as the polymeric backbone, the carbohydrate moieties and the degree of polymerization could play a role in influencing their antiviral properties.

引用

页码：90 / 96

页数：7

共 22 条

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