SINGLE VERSUS DIVIDED DAILY DOSAGES OF CLOMIPRAMINE - PLASMA-CONCENTRATION AND CLINICAL EFFECT

被引：17

作者：

DENCKER, SJ ^{[1
]}

NAGY, A ^{[1
]}

机构：

[1] SAHLGRENS HOSP,DEPT CLIN CHEM,S-41345 GOTHENBURG,SWEDEN

来源：

ACTA PSYCHIATRICA SCANDINAVICA | 1979年 / 59卷 / 03期

关键词：

clinical effects; Clomipramine; desmethylclomipramine; dosage schedule; plasma concentration;

D O I：

10.1111/j.1600-0447.1979.tb06971.x

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Sixteen depressed patients have been treated with a daily dose of 150 mg clomipramine for 20 days. Every patient received the total dose at night for 10 days and three times daily for 10 days according to a double‐blind, cross‐over design. No differences were noted between the two dose regimens, either regarding the clinical effect or the side effects. The plasma level ratio of parent drug to demethylated metabolite was higher on single than multiple doses. Copyright © 1979, Wiley Blackwell. All rights reserved

引用

页码：326 / 333

页数：8

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