SURFACE-ACTIVITIES OF PROCAINE, LIDOCAINE, AND TETRACAINE AND THEIR INTERACTION ENERGIES WITH PHOSPHOLIPID MONOLAYERS

被引：13

作者：

VILALLONGA, FA

PHILLIPS, EW

机构：

[1] College of Pharmacy, University of Florida, Gainesville, Florida

来源：

JOURNAL OF PHARMACEUTICAL SCIENCES | 1979年 / 68卷 / 03期

关键词：

Adsorption; free energies—various local anesthetics at air‐water interface; correlated with pharmacological activity; Anesthetics; local—free energies of adsorption at air‐water interface and interaction energies with phospholipid monolayers Correlated with pharmacological activity; Interaction energies—various local anesthetics with phospholipid monolayers; Phospholipid monolayers—interaction energies with various local anesthetics correlated with pharmacological activity; Surface activities—various local anesthetics;

D O I：

10.1002/jps.2600680315

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The free energies of adsorption of procaine, lidocaine, and tetracaine at the air‐water interface were estimated from plots of surface pressure (π ≤ 5 dynes/cm) against bulk concentration. Their interaction energies with dipalmitoylphosphatidylethanolamine and dipalmitoyllecithin monolayers, previously spread at the air‐water interface, were estimated from the increase of surface pressure with increasing concentrations of the subphase‐injected anesthetic. Free energies of adsorption and the interaction energies were in the order procaine < lidocaine < tetracaine and correlate with relative anesthetic potencies and the blocking of nerve conduction. Copyright © 1979 Wiley‐Liss, Inc., A Wiley Company

引用

页码：314 / 316

页数：3

共 18 条

[1] ACTION OF ANIONIC AND CATIONIC NERVE-BLOCKING AGENTS - EXPERIMENT AND INTERPRETATION [J].