HALOPERIDOL PLASMA-LEVEL MONITORING IN PEDIATRIC-PATIENTS

被引：34

作者：

MORSELLI, PL

BIANCHETTI, G

DURAND, G

LEHEUZEY, MF

ZARIFIAN, E

DUGAS, M

机构：

[1] Departement de Recherche Clinique, Synthelabo-L.E.R.S, Paris

[2] Service de Psycho-pathologie de I'Enfant et de I Adolescent, Hópital Herold, Paris

来源：

THERAPEUTIC DRUG MONITORING | 1979年 / 1卷 / 01期

关键词：

Haloperidol; Plasma concentrations; Psychoses;

D O I：

10.1097/00007691-197901000-00004

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Plasma levels of haloperidol were monitored in children and teenagers suffering from psychotic episodes and/or abnormal movements (tics and Gilles de la Tourette's syndrome). Steady-state concentrations of haloperidol ranged from 0.7 to 19 ng/ml without any apparent relationship with the administered dose (15-285 /xg/kg/day) and a 15-fold variability was observed for the same daily dosage. On the contrary, a significant (p < 0.02) relationship was found between the age of the patients and the plasma concentrations to dose ratios, lower values being present in younger patients. Side effects too appeared to be related to plasma levels, with a significant increase (p < 0.01) in incidence for concentrations over 6 ng/ml. In most of the cases suffering from tics and Gilles de la Tourette's syndrome, a positive response was associated with plasma levels of 1-4 ng/ml, while no relationship could be established for the psychotic group. The relevance of monitoring plasma drug levels when prescribing haloperidol in pediatrics is discussed. © 1979 Raven Press, New York.

引用

页码：35 / 46

页数：12

共 19 条

[1] Di Mascio A., The butyrophenones, Butyrophenones in Psychiatry, pp. 11-23, (1972)
[2] Shapiro A.K., Shapiro E., Wayne H., The psychopathology of Gilles de la Tourette's syndrome, Am J Psychiatry, 129, pp. 427-434, (1972)
[3] Woodrow K.M., Gilles de la Tourette's disease: A review, Am J Psychiatry, 131, pp. 1000-1003, (1974)
[4] Dugas M., Ferrand B.I., Fabiani N., Lejonc M., L'enfant tiqueur: Qui est-il? Comment le soulager? Quel est son devenir?, Rev Praticien, 25, pp. 3669-3678, (1975)
[5] Lake R., Ziegler M.G., Eldridge R., Murphy D.L., Catecholamine metabolism in Gilles de la Tourette's syndrome, Am J Psychiatry, 134, pp. 257-260, (1977)
[6] Gonce M., Mulot N., Dugas M., Le tic chez l'enfant et leur traitement, Medecine Et Hvgiene, 36, pp. 2274-2281, (1978)
[7] Shapiro A.K., Shapiro E.S., Bruun R.D., Sweet R.D., Gilles De La Tourette's Syndrome, (1978)
[8] Forsman A.O., Individual variability in response to haloperidol, Proc R Soc Med, 69, pp. 9-12, (1976)
[9] Forsman A., Ohman R., Pharmacokinetic studies on haloperidol in man, Curr Ther Res, 20, pp. 319-336, (1976)
[10] Forsman A., Ohman R., Applied pharmacokinetics of haloperidol in man, Curr Ther Res, 21, pp. 396-411, (1977)

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