OBSERVATIONS AND AN INTERPRETATION OF DOSE-RESPONSE RELATIONSHIPS FOR CELLULAR-TRANSFORMATION IN TERMS OF INDUCED (T)REPAIR

被引：9

作者：

CALKINS, J ^{[1
]}

EINSPENNER, M ^{[1
]}

AZZAM, E ^{[1
]}

KUNHI, M ^{[1
]}

SIGUT, D ^{[1
]}

HANNAN, M ^{[1
]}

机构：

[1] KING FAISAL SPECIALIST HOSP & RES CTR,DEPT BIOL & MED RES,RIYADH 11211,SAUDI ARABIA

来源：

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY | 1991年 / 59卷 / 01期

关键词：

D O I：

10.1080/09553009114550041

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Both radiation-induced lethality and transformation frequency have been observed to plateu or diminish abruptly at relatively low dose levels and then increase with increasing doses, but at a reduced incremental rate. Discontinuities in dose-response relationships are postulated to correspond to the induction of a repair system ('T' repair) not functional at lower doses, i.e. below the induction threshold dose (T(t)). Anomalies (discontinuities) in dose-response relationships and effects of dose fractionation previously noted are qualitatively explained in terms of this model.

引用

页码：41 / 51

页数：11

共 29 条

[1] LACK OF INVERSE DOSE-RATE EFFECT ON FISSION NEUTRON-INDUCED TRANSFORMATION OF C3H 10T1/2 CELLS [J].

BALCERKUBICZEK, EK ;

HARRISON, GH ;

ZEMAN, GH ;

MATTSON, PJ ;

KUNSKA, A .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1988, 54 (04) :531-536

[2]

BARENDSEN GW, 1985, INT J RADIAT BIOL, V47, P731

[3]

BURCH PRJ, 1986, INT J RADIAT BIOL, V49, P495

[4] ACTIVATED REPAIR OF SKIN - DAMAGE-INDUCED RADIATION REPAIR SYSTEM [J].

CALKINS, J ;

GREENLAW, RH .

RADIOLOGY, 1971, 100 (02) :389-&

[5] ULTRAVIOLET LIGHT-INDUCED REACTIVATION OF ALPHA-IRRADIATED YEAST-CELLS [J].

CALKINS, J ;

BALLARD, R ;

GILLESPIE, M .

RADIATION RESEARCH, 1978, 73 (03) :440-451

[6]

CALKINS J, 1990, STRAHLENTHER ONKOL, V166, P22

[7] AN UNUSUAL FORM OF RESPONSE IN X-IRRADIATED PROTOZOA AND A HYPOTHESIS AS TO ITS ORIGIN [J].

CALKINS, J .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY AND RELATED STUDIES IN PHYSICS CHEMISTRY AND MEDICINE, 1967, 12 (03) :297-&

[8] RESPONSES OF 2 MAMMALIAN-CELL LINES TO LOW GAMMA-RAY DOSES [J].

CALKINS, J ;

EINSPENNER, M ;

BLOCHER, D ;

GREER, W .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1989, 56 (06) :869-875

[9]

CALKINS J, 1968, J RAD BIOL, V4, P487

[10] AGE-DEPENDENT VARIATIONS IN CELLULAR-SUSCEPTIBILITY TO NEOPLASTIC TRANSFORMATION - REPLY [J].

ELKIND, MM ;

HILL, CK .

INTERNATIONAL JOURNAL OF RADIATION BIOLOGY, 1986, 50 (06) :1117-1122

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