INVITRO ACTIVITIES OF CHLOROQUINE IN COMBINATION WITH CHLORPROMAZINE OR PROCHLORPERAZINE AGAINST ISOLATES OF PLASMODIUM-FALCIPARUM

被引：26

作者：

BASCO, LK

LEBRAS, J

机构：

[1] CNRCP, Institut de Medecine, Hopital Bichat-Claude Bernard

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1992年 / 36卷 / 01期

关键词：

D O I：

10.1128/AAC.36.1.209

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The combinations of chloroquine plus chlorpromazine and chloroquine plus prochlorperazine were evaluated in vitro for potentiation against isolates of Plasmodium falciparum. Potentiation was observed against all chloroquine-resistant isolates. There was no potentiation against 8 of 10 chloroquine-susceptible isolates. The results indicated that the phenothiazines can potentiate chloroquine action against resistant parasites found in natural conditions.

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页码：209 / 213

页数：5

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