TYPE-ORIENTED THERAPY FOR GASTRIC-CANCER EFFECTIVE FOR LYMPH-NODE METASTASIS - MANAGEMENT OF LYMPH-NODE METASTASIS USING ACTIVATED CARBON PARTICLES ADSORBING AN ANTICANCER AGENT

被引：30

作者：

TAKAHASHI, T

SAWAI, K

HAGIWARA, A

TAKAHASHI, S

SEIKI, K

TOKUDA, H

机构：

[1] Department of Surgery, Kyoto Prefectural University of Medicine, Kyoto

[2] Department of Surgery, Kyoto Second Red Cross Hospital, Kyoto

来源：

SEMINARS IN SURGICAL ONCOLOGY | 1991年 / 7卷 / 06期

关键词：

GASTRIC CANCER; LYMPH NODE METASTASIS; ACTIVATED CARBON; CHEMOTHERAPY; LYMPH FLOW; MITOMYCIN-C;

D O I：

10.1002/ssu.2980070610

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Activated carbon particles are taken selectively up by lymphatics when injected into the tissues and visualize regional lymph nodes colored black. Furthermore, carbon particles adsorb a large amount of the anticancer agent mitomycin C (MMC) on their surface and release the drug reversibly. Using these properties of activated carbon particles, we have applied it for lymph node dissection and chemotherapy of lymph node metastasis. After injection of carbon particles, regional lymph nodes of the stomach were found to be black; blackened lymph nodes extending widely from perigastric to para-aortic nodes were identified from other structures. Four hundred and twenty-four patients with gastric cancer were treated with this method for lymph node metastasis during 1984-1988. Involved nodes were generally colored in high incidence, about 70% of involved ones except for highly positive nodes, which was the same as noninvolved nodes. In highly positive nodes, the colored incidence was decreased to about 48%. The cumulative 5-year survival rate of the patients treated with this series was 74.6%, which was significantly higher than the figures without this method.

引用

页码：378 / 383

页数：6

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