ANTIOXIDANT ACTIVITY OF FLAVONOIDS FROM SIDERITIS-JAVA']JAVALAMBRENSIS

被引：66

作者：

RIOS, JL ^{[1
]}

MANEZ, S ^{[1
]}

PAYA, M ^{[1
]}

ALCARAZ, MJ ^{[1
]}

机构：

[1] FAC FARM VALENCIA,DEPT FARMACOL,AVDA BLASCO IBANEZ 13,E-46010 VALENCIA,SPAIN

来源：

PHYTOCHEMISTRY | 1992年 / 31卷 / 06期

关键词：

SIDERITIS-[!text type='JAVA']JAVA[!/text]LAMBRENSIS; LABIATAE; FLAVONOIDS; ANTIOXIDANT ACTIVITY; SUPEROXIDE SCAVENGERS;

D O I：

10.1016/0031-9422(92)80338-F

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Five flavonoid glycosides, 4'-O-methylisoscutellarein 7-O-[6"-acetylallopyranosyl(1 --> 2)glucopyranoside], 4'-O-methylisoscutellarein 7-O-allopyranosyl(1 --> 2)glucopyranoside, 3'-hydroxy-4'-O-methylisoscutellarein 7-O-[6"-acetylallopyranosyl(1 --> 2)glucopyranoside], isoscutellarein 7-O-[6"-acetylallopyranosyl(1 --> 2)glucopyranoside] and hypolaetin-8-glucoside have been isolated from Sideritis javalambrensis aerial parts and identified by standard methods. These glycosides have been tested for their antioxidant properties alongside other 7,8-substituted flavonoids using FeSO4/cysteine-induced microsomal lipid peroxidation. Superoxide scavenging activity was assessed in the nitroblue tetrazolium test. Among this series of flavonoids, hypolaetin-8-glucoside is the most potent inhibitor of non-enzymic lipid peroxidation. The antiperoxidative activity of these flavonoids may be related to their superoxide scavenging ability.

引用

页码：1947 / 1950

页数：4

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