CYTOKINE REGULATION OF MURINE LEISHMANIASIS - INTERLEUKIN-4 IS NOT SUFFICIENT TO MEDIATE PROGRESSIVE DISEASE IN RESISTANT C57BL/6 MICE

被引：50

作者：

SADICK, MD

STREET, N

MOSMANN, TR

LOCKSLEY, RM

机构：

[1] UNIV CALIF SAN FRANCISCO,MED CTR,DEPT MED,DIV INFECT DIS,SAN FRANCISCO,CA 94143

[2] DNAX RES INST MOLEC & CELLULAR BIOL INC,PALO ALTO,CA 94304

来源：

INFECTION AND IMMUNITY | 1991年 / 59卷 / 12期

关键词：

D O I：

10.1128/IAI.59.12.4710-4714.1991

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutralization of interleukin 4 (IL-4) at the time of infection with Leishmania major allowed susceptible BALB/c mice to heal. Recombinant IL-4, however, had little effect on the course of L. major infection in resistant C57BL/6 mice, nor did coinfection with Nippostrongylus brasiliensis, despite marked elevation of endogenous IL-4 levels.

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页码：4710 / 4714

页数：5

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