SENILE PLAQUES AND OTHER SENILE CHANGES IN THE BRAIN OF AN AGED AMERICAN BLACK BEAR

被引：37

作者：

UCHIDA, K

YOSHINO, T

YAMAGUCHI, R

TATEYAMA, S

KIMOTO, Y

NAKAYAMA, H

GOTO, N

机构：

[1] Department of VeterinaryPathology, Faculty of Agriculture, Miyazaki University

来源：

VETERINARY PATHOLOGY | 1995年 / 32卷 / 04期

关键词：

AGED BEARS; BETA PROTEIN; SENILE PLAQUES;

D O I：

10.1177/030098589503200410

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

A female American black bear (Euarctos ursus americanus) over 20 years old had shown epileptiform neurologic signs starting in March 1992 and was found dead unexpectedly 8 months later. At necropsy, pulmonary and intrabronchial hemorrhage was noted. In the brain, the leptomeninges exhibited slight thickening, and petechiae were evident in the hippocampus. Histopathologic examination of the brain revealed several senile changes: numerous senile plaques, amyloid deposition in cerebromeningeal arterioles, mineral deposition in the pallidum, and numerous corpora amylacea in the cerebellum.

引用

页码：412 / 414

页数：3

共 10 条

[1]

Arai H., Lee M.Y.V., Otvas L., Greenberg B.D., Lowery D.E., Sharma S.K., Schmidt M.L., Trojanowski J.Q., Defined neurofilament, tau, and beta-amyloid precursor protein epitopes distinguish Alzheimer senile plaque, Proc Natl Acad Sci USA, 87, pp. 2249-2253, (1990)

[2]

Cork L.C., Powers R.E., Selkoe D.J., Davies P., Geyer J.J., Price D.L., Neurofibrillary tangles and senile plaques in aged bears, J Neuropathol Exp Neurol, 47, pp. 629-641, (1988)

[3]

Innes J.R.M., Saunders L.Z., pp. 659-667, (1962)

[4]

Joachim C.L., Morris J.H., Selkoe D.J., Diffuse plaques occur commonly in the cerebellum in Alzheimer's disease, Am J Pathol, 135, pp. 309-319, (1989)

[5]

Brody H., Harman D., Ordy J.M., (1975)

[6]

Selkoe D.J., Bell D.S., Podlisny M.B., Price D.I., Cork L.C., Conservation of brain amyloid proteins in aged mammals and humans with Alzheimer's disease, Science, 235, pp. 873-877, (1987)

[7]

Shin R.W., Iwaki T., Kitamoto T., Tateishi J., Hydrated autoclave treatment enhances tau immunoreactivity in formalin-fixed normal and Alzheimer's brain tissues, Lab Invest, 64, pp. 693-702, (1990)

[8]

Uchida K., Tani Y., Uetsuka K., Nakayama H., Goto N., Immunohistochemical studies on canine cerebral amyloid angiopathy and senile plaques, J Vet Med Sci, 54, pp. 759-771, (1992)

[9]

Wisniewski H.M., Jonson A.B., Raine C.S., Kay W.J., Terry R.D., Senile plaques and cerebral amyloidosis in aged dogs, Lab Invest, 23, pp. 287-296, (1970)

[10]

Maurer K., Riederer P., Becmann H., pp. 151-168, (1990)

← 1 →