BETA-ADRENERGIC BLOCKING AGENTS .V. 1-AMINO-3-(SUBSTITUTED PHENOXY)-2-PROPANOLS

被引：55

作者：

CROWTHER, AF

GILMAN, DJ

MCLOUGHLIN, BJ

SMITH, LH

TURNER, RW

WOOD, TM

机构：

[1] Imperial Chemical Industries Ltd., Pharmaceutical Division, Macclesfield, Cheshire, Alderly Park

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1969年 / 12卷 / 04期

关键词：

D O I：

10.1021/jm00304a018

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Several 1-amino-3-(substituted phenoxy)-2-propanols have been synthesized and tested against isoproterenolinduced tachycardia in anesthetized cats. Their β-adrenergic blocking activity proved in general to be similar to that of the propranolol analogs described in part II.1a Structure-activity relationships are discussed. Of the compounds tested, 1-isopropylamino-3-(3-methylphenoxy)-2-propanol was examined in detail in laboratory animals. © 1969, American Chemical Society. All rights reserved.

引用

页码：638 / +

页数：1

共 15 条

[1] BLACK JW, 1962, LANCET, V2, P311
[2] BRADLEY W, 1951, J CHEM SOC, P1959
[3] BETA-ADRENERGIC BLOCKING AGENTS .2. PROPRANOLOL AND RELATED 3-AMINO-I-NAPHTHOXY-2-PROPANOLS
CROWTHER, AF
SMITH, LH
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 1968, 11 (05) : 1009 - +
[4] CROWTHER AF, 1967, Patent No. 1069345
[5] CROWTHER AF, 1967, Patent No. 1069341
[6] EGGERT HG, 1957, Patent No. 1010971
[7] GILMAN DJ, 1968, Patent No. 1128052
[8] HAHNEL J, 1966, Z KREISLAUFFORSCH, V55, P1023
[9] THE SYNTHESIS AND LOCAL ANAESTHETIC PROPERTIES OF ARYLOXYPROPANOLAMINES
ING, HR
ORMEROD, WE
[J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 1952, 4 (01) : 21 - 26
[10] LEFEBVRE H, 1946, CR HEBD ACAD SCI, V222, P1439

← 1 2 →