INVOLVEMENT OF SUPEROXIDE IN THE PROLYL AND LYSYL HYDROXYLASE REACTIONS

被引:38
作者
MYLLYLA, R [1 ]
SCHUBOTZ, LM [1 ]
WESER, U [1 ]
KIVIRIKKO, KI [1 ]
机构
[1] UNIV TUBINGEN,INST PHYSIOL CHEM,D-7400 TUBINGEN 1,FED REP GER
基金
芬兰科学院;
关键词
D O I
10.1016/0006-291X(79)90948-3
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Four superoxide dismutase active copper chelates, Cu(acetylsalicylate)2, Cu(salicylate)2, Cu(lysine)2 and Cu(tyrosine)2, proved to be inhibitors of prolyl and lysyl hydroxylase. The kinetics of the inhibition are consistent with the proposal that these compounds dismutated •O2 staggered- at the active site of the enzymes. The data strongly suggest that •O2 staggered- is the active form of O2 in the prolyl and lysyl hydroxylase reactions. © 1979.
引用
收藏
页码:98 / 102
页数:5
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