THE 5HT2 RECEPTOR DEFINES A FAMILY OF STRUCTURALLY DISTINCT BUT FUNCTIONALLY CONSERVED SEROTONIN RECEPTORS

被引：313

作者：

JULIUS, D ^{[1
]}

HUANG, KN ^{[1
]}

LIVELLI, TJ ^{[1
]}

AXEL, R ^{[1
]}

JESSELL, TM ^{[1
]}

机构：

[1] COLUMBIA UNIV COLL PHYS & SURG,HOWARD HUGHES MED INST,NEW YORK,NY 10032

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1990年 / 87卷 / 03期

关键词：

cellular transformation; neurotransmitters; Phospholipase C;

D O I：

10.1073/pnas.87.3.928

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Serotonin exerts its diverse physiological effects by interacting with multiple distinct receptor subtypes. We have isolated a rat brain 5HT2 serotonin receptor cDNA by virtue of its homology with the 5HT1c receptor. The 5HT2 receptor is a member of the family of receptors that are linked to guanine nucleotide-binding proteins and are predicted to span the lipid bilayer seven times. Overall sequence identity between the 5HT2 and 5HT1c receptors is 49%, but identity within the transmembrane domains is 80%. Expression of both the 5HT2 and 5HT1c in transfected mouse fibroblasts activates phospholipase C signaling pathways and promotes cellular transformation. However, RNA blotting shows that these two receptor subtypes are differentially expressed in the central nervous sytem. In this manner, structurally and functionally homologous receptor subtypes may elicit distinct physiologic actions.

引用

页码：928 / 932

页数：5

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