TRANSFORMATION OF AUCUBIN TO NEW PYRIDINE MONOTERPENE ALKALOIDS, AUCUBININE-A AND AUCUBININE-B, BY HUMAN INTESTINAL BACTERIA

被引：28

作者：

HATTORI, M ^{[1
]}

KAWATA, Y ^{[1
]}

INOUE, K ^{[1
]}

SHU, YZ ^{[1
]}

CHE, QM ^{[1
]}

NAMBA, T ^{[1
]}

KOBASHI, K ^{[1
]}

机构：

[1] TOYAMA MED & PHARMACEUT UNIV, FAC PHARMACEUT SCI, SUGITANI, TOYAMA 2630, JAPAN

来源：

PHYTOTHERAPY RESEARCH | 1990年 / 4卷 / 02期

关键词：

Aucubin; aucubinine; intestinal bacteria; metabolism;

D O I：

10.1002/ptr.2650040207

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Aucubin was transformed to new nitrogen‐containing compounds named aucubinines A and B, along with an aglycone, aucubigenin by anaerobic incubation with defined strains of human intestinal bacteria and with faecal flora of humans. Among 24 bacterial strains examined, Klebsiella pneumoniae, Bifidobacterium breve, Bifidobacterium pseudolongum, Peptostreptococcus intermedius and Bacteroides fragilis showed potent ability of transforming aucubin to aucubinine A. Aucubinines A and B were prepared from aucubin by almond β‐glucosidase in the presence of NH 4+. Copyright © 1990 John Wiley & Sons, Ltd.

引用

页码：66 / 70

页数：5

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