EFFECT OF 3-AMINO-1,2,4-TRIAZOLE ON ETHANOL-INDUCED NARCOSIS, LETHALITY AND HYPOTHERMIA IN RATS

被引:42
作者
ARAGON, CMG
SPIVAK, K
AMIT, Z
机构
[1] Concordia University, Center for Studies in Behavioral Neurobiology, Montreal, Que. H3G 1M8
关键词
ETHANOL; NARCOSIS; LETHALITY; HYPOTHERMIA; ACETALDEHYDE; 3-AMINO-1,2,4-TRIAZOLE; CATALASE;
D O I
10.1016/0091-3057(91)90397-K
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
It has been proposed that ethanol can be oxidized in brain via the peroxidatic activity of catalase and that centrally formed acetaldehyde may mediate several of the psychopharmacological actions of ethanol. The present study was designed to investigate the role of brain catalase in the mediation of ethanol-induced narcosis, hypothermia and lethality in rats. Rats were pretreated with the catalase inhibitor 3-amino-1,2,4-triazole (AT) or saline. Five hours later, animals in each pretreatment group received IP injections of ethanol (3 or 4 g/kg). Ethanol-induced narcosis was significantly attenuated in AT-pretreated rats compared to the saline control group. As well, AT pretreatments reduced significantly the lethal effect of these ethanol doses. However, AT-pretreated ethanol-injected animals significantly reduce their body temperature as compared to the saline-ethanol animals. Blood ethanol determinations revealed that AT did interfere with ethanol metabolism. AT inhibits significantly brain catalase activity at all doses used in this study. The results indicate a role for brain catalase in ethanol effects. Furthermore, they suggest that catalase may be involved in the oxidation of ethanol in brain and that centrally formed acetaldehyde may play a role in ethanol-induced narcosis and lethality, but not hypothermia.
引用
收藏
页码:55 / 59
页数:5
相关论文
共 32 条
[1]   A MULTI-DIMENSIONAL EXAMINATION OF THE POSITIVE REINFORCING PROPERTIES OF ACETALDEHYDE [J].
AMIT, Z ;
SMITH, BR .
ALCOHOL, 1985, 2 (02) :367-370
[2]   A CORRELATION BETWEEN VOLUNTARY ETHANOL-CONSUMPTION AND BRAIN CATALASE ACTIVITY IN THE RAT [J].
ARAGON, CMG ;
STERNKLAR, G ;
AMIT, Z .
ALCOHOL, 1985, 2 (02) :353-356
[3]   ACETALDEHYDE MAY MEDIATE REINFORCEMENT AND AVERSION PRODUCED BY ETHANOL - AN EXAMINATION USING A CONDITIONED TASTE-AVERSION PARADIGM [J].
ARAGON, CMG ;
ABITBOL, M ;
AMIT, Z .
NEUROPHARMACOLOGY, 1986, 25 (01) :79-83
[4]   GENETIC-VARIATION IN ETHANOL SENSITIVITY IN C57BL/6 AND DBA/2 MICE - A FURTHER INVESTIGATION OF THE DIFFERENCES IN BRAIN CATALASE ACTIVITY [J].
ARAGON, CMG ;
AMIT, Z .
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 1987, 492 :398-400
[5]   EFFECTS OF 3-AMINO-1,2,4-TRIAZOLE ON ETHANOL-INDUCED OPEN-FIELD ACTIVITY - EVIDENCE FOR BRAIN CATALASE MEDIATION OF ETHANOLS EFFECTS [J].
ARAGON, CMG ;
SPIVAK, K ;
AMIT, Z .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1989, 13 (01) :104-108
[6]   BLOCKADE OF ETHANOL INDUCED CONDITIONED TASTE-AVERSION BY 3-AMINO-1,2,4-TRIAZOLE - EVIDENCE FOR CATALASE MEDIATED SYNTHESIS OF ACETALDEHYDE IN RAT-BRAIN [J].
ARAGON, CMG ;
SPIVAK, K ;
AMIT, Z .
LIFE SCIENCES, 1985, 37 (22) :2077-2084
[7]  
ARAGON CMG, 1991, IN PRESS BIOCH PHARM
[8]  
BRANNAN TS, 1981, J NEUROCHEM, V86, P307
[9]   AVERSIVE CONDITIONING BY PSYCHOACTIVE DRUGS - EFFECTS OF MORPHINE, ALCOHOL AND CHLORDIAZEPOXIDE [J].
CAPPELL, H ;
LEBLANC, AE ;
ENDRENYI, L .
PSYCHOPHARMACOLOGIA, 1973, 29 (03) :239-246
[10]   ETHANOL OXIDATION BY RAT-BRAIN INVIVO [J].
COHEN, G ;
SINET, PM ;
HEIKKILA, R .
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 1980, 4 (04) :366-370