NON-MYELOTOXIC ANTITUMOR EFFECTS OF L-DOPA, BUTHIONINE SULFOXIMINE AND TAMOXIFEN ON NEUROBLASTOMA-CELLS INVITRO AND INVIVO

被引:2
作者
BUSSE, E
BARTSCH, O
KORNHUBER, B
机构
[1] Zentrum der Kinderheilkunde, Abteilung für HÄmatologie und Onkologie, Johann-Wolfgang-Goethe-UniversitÄt, Frankfurt/Main 70, W-6000
关键词
BUTHIONINE SULFOXIMINE; L-DOPA; NEUROBLASTOMA; TAMOXIFEN;
D O I
10.1007/BF01612766
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effects of three non-myelotoxic cancer drugs on the growth of neuroblastoma cells were investigated in vitro and in vivo: dihydroxyphenylalanine (L-dopa, a drug with selective toxicity for melanoma cells), DL-buthionine sulphoximine (BSO, a drug with radiosensitizing effects), and tamoxifen (a drug used in the treatment of human mammary carcinoma). In vivo these substances significantly reduced the weight of neuroblastoma tumour transplants in the mice (nude/nude) (P < 0.05). A dose/effect relationship could be established. In vitro, the D50 was determined, using fibroblasts as controls. The growth of neuroblastoma tumours was inhibited by different mechanisms: L-dopa and its metabolite dopamine reduced the activity of tyrosinase, BSO reduced glutathione levels, and L-dopa and tamoxifen raised cAMP concentrations.
引用
收藏
页码:449 / 453
页数:5
相关论文
共 17 条
[1]  
BUSSE E, 1990, ONKOLOGIE, V13, P12
[2]  
BUSSE E, 1990, ONCOLOGY, V47, P199
[3]   ISOLATION AND CHARACTERIZATION OF LYMPHOCYTE PLASMA-MEMBRANES [J].
FERBER, E ;
WALLACH, DFH ;
RESCH, K ;
IMM, W .
BIOCHIMICA ET BIOPHYSICA ACTA, 1972, 266 (02) :494-&
[4]  
GOSS P, 1977, CANCER RES, V37, P152
[5]   EFFECTS OF GLUTATHIONE DEPLETION ON THE CYTOTOXICITY OF AGENTS TOWARD A HUMAN COLONIC TUMOR-CELL LINE [J].
JORDAN, J ;
DOHERTY, MD ;
COHEN, GM .
BRITISH JOURNAL OF CANCER, 1987, 55 (06) :627-631
[6]  
KABLE EPW, 1989, CANCER RES, V49, P2327
[7]   CHANGES IN CELLULAR GLUTATHIONE CONTENT DURING ADRIAMYCIN TREATMENT IN HUMAN OVARIAN-CANCER - A POSSIBLE INDICATOR OF CHEMOSENSITIVITY [J].
LEE, FYF ;
SIEMANN, DW ;
SUTHERLAND, RM .
BRITISH JOURNAL OF CANCER, 1989, 60 (03) :291-298
[8]  
LOWRY OH, 1951, J BIOL CHEM, V193, P265
[9]   GLUTATHIONE [J].
MEISTER, A ;
ANDERSON, ME .
ANNUAL REVIEW OF BIOCHEMISTRY, 1983, 52 :711-760
[10]  
MUSGROVE EA, 1989, CANCER RES, V49, P2398