POTENTIATION OF SODIUM CHROMATE(VI)-INDUCED CHROMOSOMAL-ABERRATIONS AND MUTATION BY VITAMIN-B2 IN CHINESE-HAMSTER V79-CELLS

被引：16

作者：

SUGIYAMA, M ^{[1
]}

TSUZUKI, K ^{[1
]}

LIN, XH ^{[1
]}

COSTA, M ^{[1
]}

机构：

[1] NYU MED CTR, INST ENVIRONM MED, NEW YORK, NY 10016 USA

来源：

MUTATION RESEARCH | 1992年 / 283卷 / 03期

关键词：

CHROMATE; CHROMIUM(V); VITAMIN-B2; CHROMOSOMAL ABERRATIONS; HGPRT MUTATION ASSAY;

D O I：

10.1016/0165-7992(92)90109-U

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The effect of vitamin B2, which is capable of reducing chromium(VI) to chromium(V), on chromosomal aberrations and mutation caused by Na2CrO4 was investigated in Chinese hamster V79 cells. Pretreatment with 200 muM vitamin B2 (riboflavin) for 24 h prior to exposure to Na2CrO4 (2.5-5 muM) resulted in an increase of metal-induced chromosomal aberrations and mutation at the HGPRT locus. These and other previous studies suggest that vitamin B2 enhances the clastogenic and mutagenic action of chromate compounds, through its ability to directly reduce chromium(VI) in cells.

引用

页码：211 / 214

页数：4

共 16 条

[1]

BANKS RB, 1986, BIOCHEM BIOPH RES CO, V137, P8

[2] MODIFICATION OF CHROMIUM(VI)-INDUCED DNA DAMAGE BY GLUTATHIONE AND CYTOCHROMES-P-450 IN CHICKEN-EMBRYO HEPATOCYTES [J].

CUPO, DY ;

WETTERHAHN, KE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (20) :6755-6759

[3]

De Flora S, 1989, LIFE CHEM REPORTS, V7, P169

[4] GENOTOXICITY OF CHROMIUM COMPOUNDS - A REVIEW [J].

DEFLORA, S ;

BAGNASCO, M ;

SERRA, D ;

ZANACCHI, P .

MUTATION RESEARCH, 1990, 238 (02) :99-172

[5] CHROMIUM(V)-INDUCED CLEAVAGE OF DNA - ARE CHROMIUM(V) COMPLEXES THE ACTIVE CARCINOGENS IN CHROMIUM(VI)-INDUCED CANCERS [J].

FARRELL, RP ;

JUDD, RJ ;

LAY, PA ;

DIXON, NE ;

BAKER, RSU ;

BONIN, AM .

CHEMICAL RESEARCH IN TOXICOLOGY, 1989, 2 (04) :227-229

[6] ELECTRON-PARAMAGNETIC-RES STUDY ON THE INTERACTION OF HEXAVALENT CHROMIUM WITH GLUTATHIONE OR CYSTEINE - PRODUCTION OF PENTAVALENT CHROMIUM AND ITS STABILITY [J].

KITAGAWA, S ;

SEKI, H ;

KAMETANI, F ;

SAKURAI, H .

INORGANICA CHIMICA ACTA-BIOINORGANIC CHEMISTRY, 1988, 152 (04) :251-255

[7] 100 YEARS OF CHROMIUM AND CANCER - A REVIEW OF EPIDEMIOLOGICAL EVIDENCE AND SELECTED CASE-REPORTS [J].

LANGARD, S .

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE, 1990, 17 (02) :189-215

[8] ON THE HYDROXYL RADICAL FORMATION IN THE REACTION BETWEEN HYDROGEN-PEROXIDE AND BIOLOGICALLY GENERATED CHROMIUM(V) SPECIES [J].

SHI, XL ;

DALAL, NS .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1990, 277 (02) :342-350

[9] NADPH-DEPENDENT FLAVOENZYMES CATALYZE ONE ELECTRON REDUCTION OF METAL-IONS AND MOLECULAR-OXYGEN AND GENERATE HYDROXYL RADICALS [J].

SHI, XL ;

DALAL, NS .

FEBS LETTERS, 1990, 276 (1-2) :189-191

[10] VITAMIN B2-ENHANCEMENT OF SODIUM CHROMATE(VI)-INDUCED DNA SINGLE-STRAND BREAKS - ESR STUDY OF THE ACTION OF VITAMIN-B2 [J].

SUGIYAMA, M ;

ANDO, A ;

OGURA, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 159 (03) :1080-1085

← 1 2 →