DIETHYLSTILBESTROL INDUCES NEOPLASTIC TRANSFORMATION WITHOUT MEASURABLE GENE MUTATION AT 2 LOCI

被引：183

作者：

BARRETT, JC

WONG, A

MCLACHLAN, JA

机构：

[1] NIEHS, PULM FUNCT & TOXICOL LAB, ENVIRONM CARCINOGENESIS GRP, RES TRIANGLE PK, NC 27709 USA

[2] NIEHS, REPROD & DEV TOXICOL LAB, TRANSPLACENTAL TOXICOL GRP, RES TRIANGLE PK, NC 27709 USA

来源：

SCIENCE | 1981年 / 212卷 / 4501期

关键词：

D O I：

10.1126/science.6262919

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The frequency with which diethylstilbestrol induces neoplastic transformation and somatic mutation was measured concomitantly in Syrian hamster embryo cells. While diethylstilbestrol was as active as benzo[a]pyrene in inducing transformation, it failed to induce mutations at 2 conventionally studied loci. Diethylstilbestrol may transform cells in the absence of gene mutations.

引用

页码：1402 / 1404

页数：3

共 18 条

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