ACUTE ASCENDING MYELITIS AND ENCEPHALOPATHY AFTER INTRATHECAL CYTOSINE-ARABINOSIDE AND METHOTREXATE IN AN ADOLESCENT BOY WITH ACUTE LYMPHOBLASTIC-LEUKEMIA

被引：14

作者：

OZON, A

TOPALOGLU, H

CILA, A

GUNAY, M

CETIN, M

机构：

[1] UNIV HACETTEPE,CHILDRENS HOSP,DEPT CHILD NEUROL,ANKARA 06100,TURKEY

[2] HACETTEPE UNIV,CHILDRENS HOSP,DEPT NEUROL,ANKARA,TURKEY

[3] HACETTEPE UNIV,CHILDRENS HOSP,DEPT PEDIAT,ANKARA,TURKEY

[4] HACETTEPE UNIV,CHILDRENS HOSP,DEPT RADIOL,ANKARA,TURKEY

[5] UNIV HACETTEPE,CHILDRENS HOSP,DEPT HEMATOL,ANKARA,TURKEY

来源：

BRAIN & DEVELOPMENT | 1994年 / 16卷 / 03期

关键词：

ACUTE ENCEPHALOPATHY; ACUTE LEUKEMIA; METHOTREXATE; CYTOSINE ARABINOSIDE; INTRATHECAL; CHEMICAL ARACHNOIDITIS; NEUROTOXICITY; ASCENDING MYELITIS;

D O I：

10.1016/0387-7604(94)90079-5

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A 14-year-old boy with acute lymphoblastic leukemia developed acute ascending myelitis followed by encephalopathy after intrathecal administration of methotrexate 15 mg and cytosine arabinoside 50 mg. The patient had none of the risk factors noted previously in other patients with intrathecal therapy (IT) induced neurotoxicity. The doses administered were within the standard scales, and toxicity developed in the second boost of IT 20 days after the first one. There may not be any parameters to predict the occurrence of such severe and rare form of CNS neurotoxicity attributed to IT.

引用

页码：246 / 248

页数：3

共 17 条

[1] NEUROTOXICITY AND ELEVATED CEREBROSPINAL-FLUID METHOTREXATE CONCENTRATION IN MENINGEAL LEUKEMIA [J].