FACILE SYNTHESIS OF PROTECTED C-TERMINAL PEPTIDE SEGMENTS BY FMOC/BU(T) SOLID-PHASE PROCEDURES ON N-FMOC-9-AMINO-XANTHEN-3-YLOXYMETHYL POLYSTYRENE RESIN

被引：14

作者：

CHAN, WC

WHITE, PD

BEYTHIEN, J

STEINAUER, R

机构：

[1] CALBIOCHEM NOVABIOCHEM UK LTD,NOTTINGHAM NG9 2JR,ENGLAND

[2] CALBIOCHEM NOVABIOCHEM AG,CH-448 LAUFELFINGEN,SWITZERLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1995年 / 05期

关键词：

D O I：

10.1039/c39950000589

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Side-chain protected peptidyl amides, peptidyl tert-butyl esters, and the novel peptidyl 4-[N-(oxyacetyl)-beta-alaninamide]-benzyl ester (HMP-beta-Ala-NH2 ester) have been synthesised in excellent yields on N-Fmoc-9-amino-xanthen-3-yloxymethyl polystyrene resin and selectively cleaved from the solid support using 1% trifluoroacetic acid in dichloromethane within 7-8 min.

引用

页码：589 / 592

页数：4

共 14 条

[1] PEPTIDE-SYNTHESIS .2. PROCEDURES FOR SOLID-PHASE SYNTHESIS USING N-ALPHA-FLUORENYLMETHOXYCARBONYLAMINO-ACIDS ON POLYAMIDE SUPPORTS - SYNTHESIS OF SUBSTANCE-P AND OF ACYL CARRIER PROTEIN 65-74 DECAPEPTIDE
ATHERTON, E
LOGAN, CJ
SHEPPARD, RC
[J]. JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1981, (02): : 538 - 546
[2] Atherton E, 1989, SOLID PHASE PEPTIDE
[3] BARLOS K, 1991, INT J PEPT PROT RES, V37, P513
[4] Bayer E, 1994, PEPTIDES CHEM STRUCT, P156
[5] RACEMIZATION STUDIES DURING SOLID-PHASE PEPTIDE-SYNTHESIS USING AZABENZOTRIAZOLE-BASED COUPLING REAGENTS
CARPINO, LA
EL-FAHAM, A
ALBERICIO, F
[J]. TETRAHEDRON LETTERS, 1994, 35 (15) : 2279 - 2282
[6] 1-HYDROXY-7-AZABENZOTRIAZOLE - AN EFFICIENT PEPTIDE COUPLING ADDITIVE
CARPINO, LA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1993, 115 (10) : 4397 - 4398
[7] SOLID-PHASE PEPTIDE-SYNTHESIS UTILIZING 9-FLUORENYLMETHOXYCARBONYL AMINO-ACIDS
FIELDS, GB
NOBLE, RL
[J]. INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1990, 35 (03): : 161 - 214
[8] CONVERGENT SOLID-PHASE PEPTIDE-SYNTHESIS
LLOYDWILLIAMS, P
ALBERICIO, F
GIRALT, E
[J]. TETRAHEDRON, 1993, 49 (48) : 11065 - 11133
[9] A GENERAL STRATEGY FOR THE SYNTHESIS OF LARGE PEPTIDES - THE COMBINED SOLID-PHASE AND SOLUTION APPROACH
RINIKER, B
FLORSHEIMER, A
FRETZ, H
SIEBER, P
KAMBER, B
[J]. TETRAHEDRON, 1993, 49 (41) : 9307 - 9320
[10] A NEW ACID-LABILE ANCHOR GROUP FOR THE SOLID-PHASE SYNTHESIS OF C-TERMINAL PEPTIDE AMIDES BY THE FMOC METHOD
SIEBER, P
[J]. TETRAHEDRON LETTERS, 1987, 28 (19) : 2107 - 2110

← 1 2 →