学术探索
学术期刊
新闻热点
数据分析
智能评审

COMPARISON BETWEEN THE EFFECTS OF VIP AND THE NOVEL PEPTIDE PACAP ON THE EXOCRINE PANCREATIC-SECRETION OF THE RAT

被引：26
作者：
ALONSO, RM
RODRIGUEZ, AM
GARCIA, LJ
LOPEZ, MA
CALVO, JJ
机构：
[1] UNIV SALAMANCA,FAC BIOL,DEPT FISIOL & FARMACOL,E-37008 SALAMANCA,SPAIN
[2] UNIV EXTREMADURA,DEPT FISIOL,CACERES,SPAIN
来源：
PANCREAS | 1994年 / 9卷 / 01期
关键词：
EXOCRINE PANCREATIC SECRETION; PACAP; RAT; SECRETIN; VIP;
D O I：
10.1097/00006676-199401000-00018
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
The effect of intravenous infusion of pituitary adenylate cyclase-activating peptide (PACAP) 27, a novel regulatory peptide that shows a close structural and chemical similarity to vasoactive intestinal peptide (VIP), on the rat exocrine pancreatic secretion was studied. PACAP and VIP stimulated the flow rate of exocrine pancreatic secretion (p < 0.05). However, protein output and amylase secretion were mainly stimulated by PACAP. Intravenous infusion of VIP increased the plasma levels of secretin (p < 0.05). On the other hand, PACAP released neither secretin nor VIP. Our results show: (a) both PACAP and VIP stimulate exocrine pancreatic secretion, (b) PACAP stimulation of pancreatic amylase and protein secretion is greater than that induced by VIP, and (c) PACAP probably exerts a direct effect on exocrine pancreas whereas some of the actions of VIP might be mediated by secretin.
引用
收藏
页码：123 / 128
页数：6
相关论文
共 26 条
[1]   MORPHOLOGICAL, BIOCHEMICAL AND SECRETORY STUDIES ON RAT PANCREATIC DUCTS MAINTAINED IN TISSUE-CULTURE [J].
ARGENT, BE ;
ARKLE, S ;
CULLEN, MJ ;
GREEN, R .
QUARTERLY JOURNAL OF EXPERIMENTAL PHYSIOLOGY AND COGNATE MEDICAL SCIENCES, 1986, 71 (04) :633-648
[2]   EFFECT OF VASOACTIVE-INTESTINAL-PEPTIDE, BOMBESIN AND SUBSTANCE-P ON FLUID SECRETION BY ISOLATED RAT PANCREATIC DUCTS [J].
ASHTON, N ;
ARGENT, BE ;
GREEN, R .
JOURNAL OF PHYSIOLOGY-LONDON, 1990, 427 :471-482
[3]  
Bayliss WM, 1902, J PHYSIOL-LONDON, V28, P325
[4]   INTRINSIC AND EXTRINSIC INHIBITORY SYNAPTIC INPUTS TO SUBMUCOUS NEURONS OF THE GUINEA-PIG SMALL-INTESTINE [J].
BORNSTEIN, JC ;
COSTA, M ;
FURNESS, JB .
JOURNAL OF PHYSIOLOGY-LONDON, 1988, 398 :371-390
[5]  
BRADFORD MM, 1976, ANAL BIOCHEM, V72, P248, DOI 10.1016/0003-2697(76)90527-3
[6]   PRESENCE OF HIGHLY SELECTIVE RECEPTORS FOR PACAP (PITUITARY ADENYLATE-CYCLASE ACTIVATING PEPTIDE) IN MEMBRANES FROM THE RAT PANCREATIC ACINAR CELL-LINE AR-4-2J [J].
BUSCAIL, L ;
GOURLET, P ;
CAUVIN, A ;
DENEEF, P ;
GOSSEN, D ;
ARIMURA, A ;
MIYATA, A ;
COY, DH ;
ROBBERECHT, P ;
CHRISTOPHE, J .
FEBS LETTERS, 1990, 262 (01) :77-81
[7]   THE NOVEL VIP-LIKE HYPOTHALAMIC POLYPEPTIDE PACAP INTERACTS WITH HIGH-AFFINITY RECEPTORS IN THE HUMAN NEUROBLASTOMA CELL-LINE NB-OK [J].
CAUVIN, A ;
BUSCAIL, L ;
GOURLET, P ;
DENEEF, P ;
GOSSEN, D ;
ARIMURA, A ;
MIYATA, A ;
COY, DH ;
ROBBERECHT, P ;
CHRISTOPHE, J .
PEPTIDES, 1990, 11 (04) :773-777
[8]   CHOLINERGIC MECHANISMS FOR SECRETIN RELEASE AFTER INTRADUODENAL ALKALINIZATION IN THE ANESTHETIZED RABBIT [J].
GARCIA, LJ ;
MONTERO, A ;
MINGUELA, A ;
CALVO, JJ ;
LOPEZ, MA .
EXPERIMENTAL PHYSIOLOGY, 1992, 77 (04) :601-613
[9]   DUODENAL ALKALINIZATION RELEASES SECRETIN AND VASOACTIVE INTESTINAL POLYPEPTIDE AND STIMULATES EXOCRINE PANCREATIC-SECRETION IN THE ANESTHETIZED RAT [J].
GARCIA, LJ ;
MINGUELA, A ;
MONTERO, A ;
CALVO, JJ ;
LOPEZ, MA .
DIGESTION, 1990, 47 (04) :215-225
[10]  
GARDNER JD, 1986, ANNU REV PHYSIOL, V48, P103, DOI 10.1146/annurev.ph.48.030186.000535
123