ELECTRON MICROSCOPIC ALTERATIONS IN VICINITY OF EPILEPTOGENIC COBALT-GELATINE NECROSIS IN CEREBRAL CORTEX OF RAT - A CONTRIBUTION TO ULTRASTRUCTURE OF PLASMATIC-INFILTRATION OF CENTRAL NERVOUS SYSTEM

被引:28
作者
FISCHER, J
机构
[1] Max-Planck-Institut für Psychiatrie, München
[2] Institute of Physiology, Czechoslovak Academy of Sciences, Prague
关键词
Brain Edema; Cobalt Gelatine; Electron Microscopy; Epilepsy; Experimental; Focus; Plasmatic Infiltration;
D O I
10.1007/BF00685300
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
In 25 adult rats an epileptogenic cobalt-gelatine focus was produced in a standard region of the cerebral cortex. The animals were killed successively on the 1st, 3rd, 5th, 8th, 14th, 21st and 28th day after operation and the region of the epileptogenic focus was examined electron microscopically. The earliest changes were those of oedema. Later there occurred disturbances of the astrocytic processes which cling to the basement membranes of the capillaries; the intercellular spaces widened and filled with rather E. M. dense masses and a plasmatic infiltrate" developed. Gradually this exudative substance spread even further from the capillaries. It appeared in places where the astrocytic processes were severely demaged and the dendrites were partly dissipated and it filled out the wide intercellular spaces of the neuropil. The nerve cells showed a striking resistance toward this pathological process. Sometimes they floated in the exudative masses but were partly or totally deprived of the fine neural and astrocytic processes which normally surround them. Our findings are interpreted as the ultrastructural correlate of Scholz's "plasmatic infiltration". © 1969 Springer-Verlag."
引用
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页码:201 / +
页数:1
相关论文
共 38 条
[1]   DISTRIBUTION OF FERRITIN IN CEREBRAL CORTEX OF MOUSE REVEALED BY ELECTRON MICROSCOPY [J].
BONDAREFF, W .
EXPERIMENTAL NEUROLOGY, 1964, 10 (05) :377-&
[2]  
CLAWSON CC, 1966, J COMP NEUROL, V127, P183
[3]  
COTRAN RS, 1965, AM J PATHOL, V47, P1045
[4]   RECENT DEVELOPMENTS OF THE BLOOD BRAIN BARRIER CONCEPT [J].
EDSTROM, R .
INTERNATIONAL REVIEW OF NEUROBIOLOGY, 1964, 7 :153-190
[5]  
Fischer, IN PRESS
[6]  
FISCHER J, 1968, VIRCHOWS ARCH B, V1, P201
[7]  
FISCHER J, 1967, PHYSIOL BOHEMOSLOV, V16, P272
[8]   ELECTRON MICROSCOPE FINDINGS IN EPILEPTOGENIC COBALT NECROSIS IN RAT BRAIN [J].
FISCHER, J .
EXPERIENTIA, 1968, 24 (02) :162-&
[9]  
FISCHER J, 1968, ACTA HISTOCHEM, V31, P296
[10]  
FISCHER J, 1968, ACTA HISTOCHEM, V31, P305