PORCINE GAMMA-SIGMA-LYMPHOCYTE-T SUBSETS DIFFERING IN THEIR PROPENSITY TO HOME TO LYMPHOID-TISSUE

被引：71

作者：

SAALMULLER, A ^{[1
]}

HIRT, W ^{[1
]}

REDDEHASE, MJ ^{[1
]}

机构：

[1] FED RES CTR VIRUS DIS ANIM, TUBINGEN, GERMANY

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 1990年 / 20卷 / 10期

关键词：

D O I：

10.1002/eji.1830201026

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Three types of Tcell receptors (TcR) γ/δ were identified in swine, all of which are disulfide‐bonded cell surface heterodimers. The first, a 38/40‐kDa molecule, is related to the TcR γ/δ of sheep and cattle, and defines in swine a subset of CD4−CD8− T lymphocytes that is enriched in the circulatingT lymphocyte pool. The other two receptors are private to swine. The second, a 37/40‐kDa molecule, is expressed by the major subset of CD2−CD4−CD8− T lymphocytes that is neither enriched in nor excluded from lymphoid tissue. By contrast, the third type of TcR γ/δ, a 40/46‐kDa molecule, is found on CD2+CD4−CD8− T lymphocytes accumulating in lymphoid tissue. Thus, TcR γ/δ T lymphocyte subsets differing in homing propensity are typified by the expression of distinct molecular forms of the TcR γ/δ. Copyright © 1990 Wiley‐VCH Verlag GmbH & Co. KGaA

引用

页码：2343 / 2346

页数：4

共 15 条

[1] TRANSGENIC MICE DEMONSTRATE THAT EPITHELIAL HOMING OF GAMMA-DELTA-T-CELLS IS DETERMINED BY CELL LINEAGES INDEPENDENT OF T-CELL RECEPTOR SPECIFICITY [J].