A CONCISE ASYMMETRIC-SYNTHESIS OF THE POTENT ENKEPHALINASE INHIBITOR KELATORPHAN

被引：3

作者：

DJURIC, SW

机构：

[1] Gastrointestinal Diseases Research, Searle, Skokie, IL

来源：

SYNTHETIC COMMUNICATIONS | 1992年 / 22卷 / 06期

关键词：

D O I：

10.1080/00397919208020851

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise asymmetric synthesis of the enkephalinase inhibitor Kelatorphan has been completed in seven steps from commercially available hydrocinnamyl chloride. The synthesis features as a key step an asymmetric C-C bond formation which utilizes Oppolzer bornane-sultam alkylation methodology.

引用

页码：871 / 882

页数：12

共 4 条

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MORETTI, R
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[3] RAPID CHROMATOGRAPHIC TECHNIQUE FOR PREPARATIVE SEPARATIONS WITH MODERATE RESOLUTION
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