HUMORAL IMMUNE-RESPONSE IN ATLANTIC SALMON, SALMO-SALAR L, TO CELLULAR AND EXTRACELLULAR ANTIGENS OF AEROMONAS-SALMONICIDA

被引：64

作者：

LUND, V ^{[1
]}

JORGENSEN, T ^{[1
]}

HOLM, KO ^{[1
]}

EGGSET, G ^{[1
]}

机构：

[1] UNIV TROMSO,FDN APPL RES,N-9001 TROMSO,NORWAY

来源：

JOURNAL OF FISH DISEASES | 1991年 / 14卷 / 04期

关键词：

D O I：

10.1111/j.1365-2761.1991.tb00596.x

中图分类号：

S9 [水产、渔业];

学科分类号：

0908 ;

摘要：

The putative virulence factors of Aeromonas salmonicida, the aetiological agent of furunculosis in salmonids, are candidates for protective antigens in effective vaccines against furunculosis. In this report, the authors have compared the immunogenicity of cell-associated and extracellular antigens of A. salmonicida in Atlantic salmon, Salmo salar L., to that in rabbit. The animals were immunized with formalin-killed whole cells and formalin-inactivated extracellular products (ECP), either separately or in combination. The ability of the antigens to induce antibody production was studied by ELISA and Western blotting techniques. These results confirm previous reports that far more structures are immunogenic in rabbit compared to the antibody responses elicited in salmon. However, in both species, some antigens were dominant, including a caseinolytic protease in addition to the A-protein and high and low MW LPS.

引用

页码：443 / 452

页数：10

共 26 条

[1] IMMUNIZATION OF BROOK TROUT (SALVELINUS-FONTINALIS) AGAINST AEROMONAS-SALMONICIDA - IMMUNOGENICITY OF VIRULENT AND AVIRULENT ISOLATES AND PROTECTIVE ABILITY OF DIFFERENT ANTIGENS [J].