NATURALLY-OCCURRING PYRROLIZIDINES - INHIBITION OF ALPHA-GLUCOSIDASE-1 AND ANTI-HIV ACTIVITY OF ONE STEREOISOMER

被引：62

作者：

TAYLOR, DL

NASH, R

FELLOWS, LE

KANG, MS

TYMS, AS

机构：

[1] ROYAL BOT GARDENS,RICHMOND TW9 3DS,SURREY,ENGLAND

[2] MARION MERRELL DOW RES INST,CINCINNATI,OH

来源：

ANTIVIRAL CHEMISTRY & CHEMOTHERAPY | 1992年 / 3卷 / 05期

关键词：

D O I：

10.1177/095632029200300504

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Alexine, a naturally occurring pyrrolizidine alkaloid, isolated from Alexa leiopetala, and four stereoisomers, isolated from Castanospermum australe, were investigated for inhibitory activity against the growth of HIV-1. Only treatment with the 7,7a-diepialexine restricted virus growth (IC50 0.38 mM) although it was less active than the indolizidine alkaloid castanospermine (IC50 0.02 mM). The antiviral effects of 7,7a-diepialexine, like castanospermine, correlated with the inhibitory activity against purified pig kidney alpha-glucosidase 1 of the glycoprotein processing enzymes and the reduced cleavage of the precursor HIV-1 glycoprotein gp160.

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页码：273 / 277

页数：5

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