THE IMPORTANCE OF TRIGLYCERIDES - RESULTS FROM THE PROSPECTIVE CARDIOVASCULAR MUNSTER (PROCAM) STUDY

被引：56

作者：

ASSMANN, G

SCHULTE, H

机构：

[1] Institut für Klinische Chemie and Laboratoriumsmedizin, Zentrallaboratorium der Universität Munster Albert-Schweitzer Straße 33, Münster

来源：

EUROPEAN JOURNAL OF EPIDEMIOLOGY | 1992年 / 8卷

关键词：

TRIGLYCERIDES; PROCAM STUDY; ATHEROSCLEROSIS; RISK FACTOR; CHD INCIDENCE;

D O I：

10.1007/BF00145359

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In the PROCAM study hypertriglyceridaemia was much more common among men (18.6%) than women (4.2%). Prevalence increased with age in women, but remained nearly constant at about 20% in men aged 35 years or more. In a multiple regression analysis a strong negative correlation between triglycerides and HDL cholesterol was found. A positive relationship was observed with cholesterol, blood glucose, factor VIIc, and PAI-1 in both sexes. Only in men triglycerides are positively correlated with Apo A-I, body mass index, cigarette smoking, and alcohol consumption. Postmenopausal women showed higher triglyceride levels than premenopausal women. No independent relationships were observed to age, blood pressure, Lp(a), Apo A-II, Apo B, AT-III, protein C, fibrinogen, and oral contraceptives. A longitudinal analysis of data from 4474 male PROCAM participants aged 40-64 years with a follow-up of 4 years did not identify triglycerides as an independent risk factor, but the data suggest hypertriglyceridaemia is an additional risk factor for CHD, when excessive triglycerides coincide with a high ratio of plasma cholesterol to HDL-cholesterol and with low HDL-cholesterol values.

引用

页码：99 / 103

页数：5

共 23 条

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