TREATMENT OF PARKINSONS-DISEASE WITH THE PARTIAL DOPAMINE AGONIST EMD 49980

被引：19

作者：

BRAVI, D ^{[1
]}

DAVIS, TL ^{[1
]}

MOURADIAN, MM ^{[1
]}

CHASE, TN ^{[1
]}

机构：

[1] NINCDS,RHEUMATOL BRANCH,BLDG 10,ROOM SC103,BETHESDA,MD 20892

来源：

MOVEMENT DISORDERS | 1993年 / 8卷 / 02期

关键词：

EMD; 49980; DYSKINESIA; PARTIAL DOPAMINE AGONIST;

D O I：

10.1002/mds.870080214

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The motor effects of the partial dopamine agonist EMD 49980 were evaluated in parkinsonian patients under controlled conditions. EMD 49980 monotherapy resulted in a mild improvement in parkinsonian symptoms, but when co-admistered with levodopa, had no significant effect on dyskinesias or on the antiparkinsonian effect of the dopamine precursor. These results suggest that EMD 49980 exerts a net weak dopamine agonist effect but fails to ameliorate levodopa-induced dyskinesias.

引用

页码：195 / 197

页数：3

共 11 条

[1] PARTIAL DOPAMINE AGONIST THERAPY OF LEVODOPA-INDUCED DYSKINESIAS
BARONTI, F
MOURADIAN, MM
CONANT, KE
GIUFFRA, M
BRUGHITTA, G
CHASE, TN
[J]. NEUROLOGY, 1992, 42 (06) : 1241 - 1243
[2] DOPAMINE-RECEPTOR AGONISTS - MECHANISMS UNDERLYING AUTORECEPTOR SELECTIVITY .1. REVIEW OF THE EVIDENCE
CLARK, D
HJORTH, S
CARLSSON, A
[J]. JOURNAL OF NEURAL TRANSMISSION, 1985, 62 (1-2) : 1 - 52
[3] THERAPEUTIC EFFICACY OF A PARTIAL DOPAMINE AGONIST IN DRUG-FREE PARKINSONIAN-PATIENTS
CORSINI, GU
BONUCCELLI, U
RAINER, E
DELZOMPO, M
[J]. JOURNAL OF NEURAL TRANSMISSION, 1985, 64 (02) : 105 - 111
[4] D-2 DOPAMINE AUTORECEPTOR SELECTIVE DRUGS - DO THEY REALLY EXIST
DRUKARCH, B
STOOF, JC
[J]. LIFE SCIENCES, 1990, 47 (05) : 361 - 376
[5] PARKINSONISM - ONSET PROGRESSION AND MORTALITY
HOEHN, MM
YAHR, MD
[J]. NEUROLOGY, 1967, 17 (05) : 427 - &
[6] PYRIDOXINE FOR LEVODOPA-INDUCED DYSTONIA
JAMESON, HD
[J]. JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1970, 211 (10): : 1700 - &
[7] ATTEMPTED USE OF HALOPERIDOL IN TREATMENT OF L-DOPA INDUCED DYSKINESIAS
KLAWANS, HL
WEINER, WJ
[J]. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1974, 37 (04) : 427 - 430
[8] AROMATIC L-AMINO-ACID DECARBOXYLASE IN RAT CORPUS STRIATUM - IMPLICATIONS FOR ACTION OF L-DOPA IN PARKINSONISM
MELAMED, E
HEFTI, F
PETTIBONE, DJ
LIEBMAN, J
WURTMAN, RJ
[J]. NEUROLOGY, 1981, 31 (06) : 651 - 655
[9] MOTOR FLUCTUATIONS IN PARKINSONS-DISEASE - PATHOGENETIC AND THERAPEUTIC STUDIES
MOURADIAN, MM
JUNCOS, JL
FABBRINI, G
CHASE, TN
[J]. ANNALS OF NEUROLOGY, 1987, 22 (04) : 475 - 479
[10] PATHOGENESIS OF DYSKINESIAS IN PARKINSONS-DISEASE
MOURADIAN, MM
HEUSER, IJE
BARONTI, F
FABBRINI, G
JUNCOS, JL
CHASE, TN
[J]. ANNALS OF NEUROLOGY, 1989, 25 (05) : 523 - 526

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