INDUCTION OF TUMOR-NECROSIS-FACTOR IN MICE BY RECOMBINANT HUMAN MACROPHAGE-COLONY-STIMULATING FACTOR

被引:19
作者
SAKURAI, T
SUZU, S
YAMADA, M
YANAI, N
KAWASHIMA, T
HATAKE, K
TAKAKU, F
MOTOYOSHI, K
机构
[1] NATL DEF MED COLL,DEPT INTERNAL MED 3,TOKOROZAWA,SAITAMA 359,JAPAN
[2] MORINAGA MILK IND CO LTD,BIOCHEM RES LAB,KANAGAWA 228,JAPAN
[3] JICHI MED SCH,DEPT INTERNAL MED,DIV HEMATOL,TOCHIGI 32904,JAPAN
[4] NATL MED CTR,SHINJUKU KU,TOKYO,TOKYO 162,JAPAN
来源
JAPANESE JOURNAL OF CANCER RESEARCH | 1994年 / 85卷 / 01期
关键词
LPS; M-CSF; PRIMING EFFECT; TNF PRODUCTION;
D O I
10.1111/j.1349-7006.1994.tb02889.x
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The effect of recombinant human macrophage colony-stimulating factor (rhM-CSF) on endogenous production of tumor necrosis factor (TNF) was investigated in mice. The intravenous injection of lipopolysaccharide (LPS) after the administration of rhM-CSF via the same route induced the production of endogenous cytotoxic activity in serum as assessed by using TNF-sensitive murine L929 cells. The intravenous injection of LPS alone or rhM-CSF alone did not induce cytotoxic activity. The priming effect of rhM-CSF was transient and the optimal duration between injections of primer and trigger was 3 h, while the optimal duration between trigger injection and serum sampling was 1 h after LPS injection. Moreover, preinjection of rhM-CSF enhanced the priming effect of recombinant mouse interferon-gamma. No triggering effect of rhM-CSF was observed. The cytotoxic activity in the serum was completely neutralized by anti mouse TNF alpha polyclonal antibody. These results indicate that rhM-CSF can be used as a priming agent for endogenous production of TNF in vivo, and raise the possibility of using rhM-CSF in cancer immunotherapy.
引用
收藏
页码:80 / 85
页数:6
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