DNA-DAMAGE, ONCOGENESIS AND THE P53 TUMOR-SUPPRESSOR GENE

被引：55

作者：

LEE, JM

ABRAHAMSON, JLA

BERNSTEIN, A

机构：

[1] MT SINAI HOSP,SAMUEL LUNENFELD RES INST,DIV MOLEC & DEV BIOL,TORONTO M5G 1X5,ON,CANADA

[2] UNIV TORONTO,DEPT MOLEC & MED GENET,TORONTO M5S 1A8,ON,CANADA

来源：

MUTATION RESEARCH | 1994年 / 307卷 / 02期

关键词：

DNA DAMAGE; ONCOGENESIS; P53 TUMOR-SUPPRESSOR GENES; TUMOR-SUPPRESSOR GENE; TRANSCRIPTION FACTOR; TRANSGENES;

D O I：

10.1016/0027-5107(94)90267-4

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The p53 tumour-suppressor gene encodes a transcription factor which plays a central role in controlling oncogenic development in mouse and humans. Mice which over-express mutant p53 transgenes or have a homozygous deletion of the p53 gene show a high frequency of spontaneous tumour development. This review will focus on recent developments using these transgenic and null mice which suggest that p53 is important in maintaining genomic stability, and is a critical component in the cellular response to ionizing radiation.

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页码：573 / 581

页数：9

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