ENANTIOMER SEPARATION BY GAS-CHROMATOGRAPHY ON CHIRAL STATIONARY PHASES

被引：123

作者：

SCHURIG, V

机构：

[1] Institut für Organische Chemie, Universität Tübingen

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 666卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(94)80374-9

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The analytical separation of enantiomers by capillary gas chromatography on chiral stationary phases (CSPs) is reviewed. Inherent principles and methodological advances are described. Three principal CSPs tailored for hydrogen bonding, coordination and inclusion are currently employed. Cyclodextrin derivatives have proved to be the most versatile and universal CSPs in gas chromatography. Anchoring the CSPs to a polysiloxane backbone leads to Chirasil-type stationary phases with improved temperature stability, efficiency and lifetimes. Immobilization of Chirasil-type stationary phases allows enantiomer separations also in capillary supercritical fluid chromatography and capillary electrochromatography. Thermodynamic parameters of enantioselectivity in gas chromatography, kinetic studies of enantiomerization and methods of enantiomer labelling are discussed.

引用

页码：111 / 129

页数：19

共 114 条

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