EFFECTS OF BRAIN-TISSUE HYDROLYSATE ON SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS

被引：20

作者：

BASKYS, A

WOJTOWICZ, JM

机构：

[1] UNIV TORONTO,MRC,NERVE CELLA & SYNAPES GRP,DEPT PSYCHIAT,TORONTO M5T 1R8,ON,CANADA

[2] CLARKE INST PSYCHIAT,TORONTO M5T 1R8,ON,CANADA

来源：

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 1994年 / 49卷 / 04期

关键词：

CEREBROLYSIN; EXCITATORY SYNAPTIC TRANSMISSION; PEPTIDES; HIPPOCAMPAL SLICES; RAT;

D O I：

10.1016/0091-3057(94)90272-0

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

A mix of peptides and amino acids obtained from porcine brain tissue (Cerebrolysin) has been shown to affect passive avoidance behavior in neonatal rats. To identify the active components and mechanisms of action, Cerebrolysin effects were studied in in vitro hippocampal slices. Cerebrolysin induced dose-dependent suppression followed by a small rebound increase of synaptic responses in the CA1 but not dentate gyrus neurons. These actions may be due to peptides present in Cerebrolysin and may contribute to its reported behavioural effects.

引用

页码：1105 / 1107

页数：3

共 16 条

[1]

AKAI F, 1992, HISTOL HISTOPATHOL, V7, P213

[2] MEMORY DEFICITS ASSOCIATED WITH SENESCENCE - NEUROPHYSIOLOGICAL AND BEHAVIORAL-STUDY IN THE RAT [J].