INFLUENCE OF DERIVATIZATION ON THE CHIRAL SELECTIVITY OF CYCLODEXTRINS - ALKYLATED ACYLATED CYCLODEXTRINS AND GAMMA/DELTA-LACTONES AS AN EXAMPLE

被引：44

作者：

SCHMARR, HG

MOSANDL, A

KAUNZINGER, A

机构：

[1] Institut für Lebensmittelchemie, Johann Wolfgang Goethe-Universität, Frankfurt, W-6000

[2] Institut für Organische Chemie, Johann Wolfgang Goethe-Universität Niederurseler Hang, Frankfurt, W-6000, Niederurseler slope

来源：

JOURNAL OF MICROCOLUMN SEPARATIONS | 1991年 / 3卷 / 05期

关键词：

CAPILLARY GAS CHROMATOGRAPHY; CYCLODEXTRIN STATIONARY PHASES; CHIRAL RECOGNITION MECHANISM; GAMMA-LACTONES DELTA-LACTONES; CYCLODEXTRIN DERIVATIVES NMR; ENANTIOMERS;

D O I：

10.1002/mcs.1220030503

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Selectively alkylated and acylated cyclodextrin derivatives are suitable stationary phases for capillary GC. To obtain a closer insight into the separation mechanism, an inverse substituted cyclodextrin derivative was synthesized and characterized, and its chiral selectivity was compared with a traditionally substituted and characterized cyclodextrin. The influence of a polar group in the cyclodextrin molecule on the enantioselectivity for gamma-/delta-lactones is shown with a new, diacylated, cyclodextrin derivative.

引用

页码：395 / 402

页数：8

共 12 条

[1] Schurig V., Nowotny H.-P., Gaschromatographische Enantiomerentrennung an Cyclodextrinderivaten, Angewandte Chemie, 102, (1990)
[2] Ciucanu I., Kerek F., Carbohydr. Res., 131, (1984)
[3] Konig W.A., Lutz S., Colberg C., Schmidt N., Wenz G., von der Bey E., Mosandl A., Gunther C., Kustermann A., Cyclodextrins as chiral stationary phases in capillary gas chromatography. Part III: Hexakis(3-O-acetyl-2,6-di-O-pentyl)-α-cyclodextrin, Journal of High Resolution Chromatography, 11, (1988)
[4] Konig W.A., Krebber R., Wenz G., Enantioselective capillary gas chromatography on the basis of host-guest interactions with modified cyclodextrins, Journal of High Resolution Chromatography, 12, (1989)
[5] Konig W.A., Krebber R., Mischnik P., Cyclodextrins as chiral stationary phases in capillary gas chromatography. Part V: Octakis(3-O-butyryl-2,6-di-O-pentyl)-γ-cyclodextrin, Journal of High Resolution Chromatography, 12, (1989)
[6] Li W.-Y., Jin H.L., Armstrong D.W., J. Chromatogr., 509, (1990)
[7] Schmarr H.-G.
[8] Takeo K., Uemura K., Mitoh H., Derivatives Of α-Cyclodextrin and the Synthesis of 6-O-α-D-Glucopyranosyl-α-Cyclodextrin, Journal of Carbohydrate Chemistry, 7, (1988)
[9] Grob K., Making and Manipulating Capillary Columns for Gas Chromatography, (1986)
[10] Grob K., Grob G., Grob K., J. Chromatogr., 156, (1978)

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