VENTRAL MESENCEPHALIC PARTIAL-DERIVATIVE OPIOID RECEPTORS ARE INVOLVED IN MODULATION OF BASAL MESOLIMBIC DOPAMINE NEUROTRANSMISSION - AN ANATOMICAL LOCALIZATION STUDY

被引：24

作者：

DEVINE, DP ^{[1
]}

LEONE, P ^{[1
]}

CARLEZON, WA ^{[1
]}

WISE, RA ^{[1
]}

机构：

[1] CONCORDIA UNIV,DEPT PSYCHOL,CTR STUDIES BEHAV NEUROBIOL,ROOM H-1013,1455 MAISONNEUVE BLVD,MONTREAL H3G 1M8,QUEBEC,CANADA

来源：

BRAIN RESEARCH | 1993年 / 622卷 / 1-2期

关键词：

MICRODIALYSIS; DOPAMINE; OPIOID; PARTIAL-DERIVATIVE RECEPTOR; VENTRAL TEGMENTAL AREA; NUCLEUS ACCUMBENS;

D O I：

10.1016/0006-8993(93)90843-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Microdialysis was used to examine the anatomical localization of mesencephalic partial derivative opioid receptors that participate in modulation of mesolimbic dopamine (DA) neurotransmission. Independent groups of rats were injected with DPDPE into the ventral tegmental area (VTA) or interpeduncular nucleus (IPN). Extracellular nucleus accumbens DA and DOPAC concentrations were elevated after DPDPE injections into either site, but injections into the VTA were effective at lower doses than were injections into the IPN. Thus, it appears that the DA-modulating actions of DPDPE are mediated in the VTA rather than the IPN.

引用

页码：348 / 352

页数：5

共 28 条

[1] CHARACTERIZATION OF [H-3][ 2-D-PENICILLAMINE, 5-D-PENICILLAMINE] ENKEPHALIN BINDING TO DELTA-OPIATE RECEPTORS IN THE RAT-BRAIN AND NEUROBLASTOMA-GLIOMA HYBRID CELL-LINE (NG-108-15) [J].