MANAGEMENT OF SPASTICITY IN CEREBRAL-PALSY WITH BOTULINUM-A TOXIN - REPORT OF A PRELIMINARY, RANDOMIZED, DOUBLE-BLIND TRIAL

被引：249

作者：

KOMAN, LA

MOONEY, JF

SMITH, BP

GOODMAN, A

MULVANEY, T

机构：

[1] Department of Orthopaedics, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC

来源：

JOURNAL OF PEDIATRIC ORTHOPAEDICS | 1994年 / 14卷 / 03期

关键词：

BOTULINUM-A TOXIN; CEREBRAL PALSY; DYNAMIC JOINT CONTRACTURE; SPASTICITY;

D O I：

10.1097/01241398-199405000-00005

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

In order to evaluate further the efficacy of local intramuscular injections of botulinum-A toxin (BAT-A) in the management of dynamic equinus deformity associated with cerebral palsy, a randomized, double-blind, placebo-controlled study was undertaken. When evaluated using our Physician Rating Scale, 83% (five of six) of patients receiving toxin showed improvement, versus 33% (two of six) receiving placebo. There were no major complications. BAT-A injections appear to be safe and effective in children, and merit further prospective study.

引用

页码：299 / 303

页数：5

共 36 条

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