INHALED ICI-204,219 BLOCKS ANTIGEN-INDUCED BRONCHOCONSTRICTION IN SUBJECTS WITH BRONCHIAL-ASTHMA

被引：27

作者：

NATHAN, RA ^{[1
]}

GLASS, M ^{[1
]}

MINKWITZ, MC ^{[1
]}

机构：

[1] ZENECA,PHARMACEUT GRP,WILMINGTON,DE

来源：

CHEST | 1994年 / 105卷 / 02期

关键词：

D O I：

10.1378/chest.105.2.483

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

Three inhalation formulations of ICI 204,219 were compared for antagonism of antigen-induced bronchoconstriction in 16 subjects with asthma who demonstrated reproducible hypersensitivity to alIergen during screening challenges. Each subject received a single 0.2-mg dose of each formulation and was challenged with ragweed 30 min after administration of ICI 204,219 until the forced expiratory volume in 1 s (FEV(1)) decreased by 20 percent or the maximum allergen concentration (100 mu g/ml) was reached. The majority of subjects tolerated 100 mu g/ml of allergen without a 20 percent decrease in FEV(1). Inhalation formulations of ICI 204,219 successfully inhibited bronchoconstriction in subjects with reproducible sensitivity to ragweed challenges.

引用

页码：483 / 488

页数：6

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