ENDOGENOUS NITRIC-OXIDE IN EXPIRED AIR - EFFECTS OF ACUTE EXERCISE IN HUMANS

被引：64

作者：

BAUER, JA

WALD, JA

DORAN, S

SODA, D

机构：

[1] Department of Pharmaceutics, School of Pharmacy State University of New York at Buffalo, Buffalo

来源：

LIFE SCIENCES | 1994年 / 55卷 / 24期

关键词：

NITRIC OXIDE; EXPIRED AIR; PULMONARY ENDOTHELIAL CELLS;

D O I：

10.1016/0024-3205(94)00522-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Nitric oxide (NO) is present in the exhaled breath of humans and experimental animals, but its physiologic role and cellular source(s) remain to be determined. Possible sites of origin are pulmonary endothelial cells and/or resident macrophages. Here we have tested the hypothesis that changes in cardiovascular status can alter the apparent pulmonary excretion of NO. Exercise on a stationary bicycle produced rapid and reversible increases in pulmonary NO excretion rate, and changes in NO excretion rate during exercise were well correlated with observed changes in heart rate. These results suggest that changes in expired NO during exercise are related to corresponding cardiovascular responses.

引用

页码：1903 / 1909

页数：7

共 20 条

[1]

BAUER JA, 1994, LIFE SCI, V54

[2]

MEASUREMENT OF EXHALED NITRIC-OXIDE IN MAN [J].