STRUCTURE OF TREHALOSTATIN - A POTENT AND SPECIFIC INHIBITOR OF TREHALASE

被引：48

作者：

NAKAYAMA, T

AMACHI, T

MURAO, S

SAKAI, T

SHIN, T

KENNY, PTM

IWASHITA, T

ZAGORSKI, M

KOMURA, H

NOMOTO, K

机构：

[1] SUNBOR,SUNTORY INST BIOORGAN RES,OSAKA 618,JAPAN

[2] SUNTORY LTD,INST FUNDAMENTAL RES,OSAKA 618,JAPAN

[3] KUMAMOTO INST TECHNOL,DEPT APPL MICROBIAL TECHNOL,KUMAMOTO 860,JAPAN

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1991年 / 14期

关键词：

D O I：

10.1039/c39910000919

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A structural study of trehalostatin 1, a specific inhibitor of blowfly trehalase, revealed that 1 contains an unusual five-membered pseudocyclitol.

引用

页码：919 / 921

页数：3

共 10 条

[1] C-13 NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY OF MONOSACCHARIDES [J].

BOCK, K ;

PEDERSEN, C .

ADVANCES IN CARBOHYDRATE CHEMISTRY AND BIOCHEMISTRY, 1983, 41 :27-66

[2] ISOLATION AND CHARACTERIZATION OF A NEW TREHALASE INHIBITOR, S-GI [J].

MURAO, S ;

MIYATA, S .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1980, 44 (01) :219-221

[3] A NOVEL TREHALASE INHIBITOR, TREHALOSTATIN, PRODUCED BY AMYCOLATOPSIS-TREHALOSTATICA HG-25 [J].

MURAO, S ;

SAKAI, T ;

GIBO, H ;

NAKAYAMA, T ;

SHIN, T .

AGRICULTURAL AND BIOLOGICAL CHEMISTRY, 1991, 55 (03) :895-897

[4]

PERLIN AS, 1976, MTP INT REV SCI OR 2, V7, P1

[5]

PERLIN AS, 1973, ADV CHEM, V117, P39

[6] DEUTERIUM-INDUCED DIFFERENTIAL ISOTOPE SHIFT C-13 NMR .1. RESONANCE RE-ASSIGNMENTS OF MONOSACCHARIDES AND DISACCHARIDES [J].

PFEFFER, PE ;

VALENTINE, KM ;

PARRISH, FW .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (05) :1265-1274

[7]

SHIGEMOTO R, 1989, Annals of the Phytopathological Society of Japan, V55, P238, DOI 10.3186/jjphytopath.55.238

[8] CARBODIIMIDE-REACTIVE CARBOXYL GROUPS AT THE ACTIVE-SITE OF AN INSECT MIDGUT TREHALASE [J].

TERRA, WR ;

TERRA, ICM ;

FERREIRA, C ;

DEBIANCHI, AG .

BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 571 (01) :79-85

[9] PHYSICAL-PROPERTIES AND TRIS INHIBITION OF AN INSECT TREHALASE AND A THERMODYNAMIC APPROACH TO NATURE OF ITS ACTIVE-SITE [J].

TERRA, WR ;

FERREIRA, C ;

DEBIANCHI, AG .

BIOCHIMICA ET BIOPHYSICA ACTA, 1978, 524 (01) :131-141

[10]

YAMADA YN, 1987, J ANTIBIOT, V40, P563

← 1 →