ANESTHETIC AGENTS INDUCE HUMAN MONONUCLEAR LEUKOCYTES TO RELEASE CYTOKINES

被引:48
作者
ROSSANO, F
TUFANO, R
DELERO, GC
SERVILLO, G
BARONI, A
TUFANO, MA
机构
[1] NAPLES UNIV,FAC MED & CHIRURG 1,IST MICROBIOL,LARGGETTO S ANIELLO A CAPONAPOLI 2,I-80138 NAPLES,ITALY
[2] NAPLES UNIV,FAC MED & CHIRURG 2,CATTEDRA ANESTESIA & RIANIMAZ,I-80138 NAPLES,ITALY
关键词
D O I
10.3109/08923979209005403
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Studies were carried out on the ability of some anesthetic agents (Propofol, Dormicum, Ketalar and Penthotal) to induce the release of cytokines by human monocytes and lymphocytes in vitro. All anesthetic agents tested at hematic concentrations reached during anesthetic administration cause an increase in the production of Tumor necrosis factor (TNF) from human monocytes; the increase is 4-5 times greater than controls. The greatest Interleukin -1-alpha (IL-1-alpha) production increase was induced by Propofol. The release of Interleukin -6 (IL-6) is notably increased by Ketalar (about 10 times greater than controls). In the presence of different anesthetic agents, human lymphocytes release Interleukin -4 (IL-4) and Interferon-gamma- (IFN-gamma). Penthotal and Ketalar increase IL-4 production which appears quite high compared to that obtained with Con A used as standard challenge. Propofol induce IL-4 release which is about the same as that seen with Con A. IFN-gamma is released in high quantities by lymphocytes treated with Propofol. Dormicum, Ketalar and Penthotal induce non-significant increase of IFN-gamma release. The results concern the choice of anesthetic, in relation to its action on host immune response. This aspect is particularly interesting in immunocompromised host.
引用
收藏
页码:439 / 450
页数:12
相关论文
共 30 条
[1]  
BLANCHARD DK, 1986, J IMMUNOL, V136, P936
[2]   INTERFERONS AND THE IMMUNE-SYSTEM [J].
BLOOM, BR .
NATURE, 1980, 284 (5757) :593-595
[3]   HUMAN RECOMBINANT INTERLEUKIN-4 INDUCES NORMAL B-CELLS TO PRODUCE SOLUBLE CD23/IGE-BINDING FACTOR ANALOGOUS TO THAT SPONTANEOUSLY RELEASED BY LYMPHOBLASTOID B-CELL LINES [J].
BONNEFOY, JY ;
DEFRANCE, T ;
PERONNE, C ;
MENETRIER, C ;
ROUSSET, F ;
PENE, J ;
DEVRIES, JE ;
BANCHEREAU, J .
EUROPEAN JOURNAL OF IMMUNOLOGY, 1988, 18 (01) :117-122
[4]  
CLAYES H, 1982, BRIT J HAEMATOL, V50, P85
[5]   INTERLEUKIN-1 [J].
DINARELLO, CA .
REVIEWS OF INFECTIOUS DISEASES, 1984, 6 (01) :51-95
[6]  
DUNCAN PG, 1976, ANESTHESIOLOGY, V45, P522
[7]   BIOLOGICAL AND BIOCHEMICAL-CHARACTERIZATION OF MACROPHAGE ACTIVATING FACTOR (MAF) IN MURINE LYMPHOCYTES - PHYSICOCHEMICAL SIMILARITY OF MAF TO GAMMA INTERFERON (IFN-GAMMA) [J].
FUKAZAWA, Y ;
KAGAYA, K ;
MIURA, H ;
SHINODA, T ;
NATORI, K ;
YAMAZAKI, S .
MICROBIOLOGY AND IMMUNOLOGY, 1984, 28 (06) :691-702
[8]  
GAUDIE J, 1987, P NATL ACAD SCI USA, V84, P7251
[9]  
HIRANO TK, 1985, NATURE, V324, P73
[10]  
KUPPER T, 1987, J IMMUNOL, V138, P4280