THE POSTANTIFUNGAL EFFECT OF 5-FLUOROCYTOSINE ON CANDIDA-ALBICANS

被引：17

作者：

SCALARONE, GM ^{[1
]}

MIKAMI, Y ^{[1
]}

KURITA, N ^{[1
]}

YAZAWA, K ^{[1
]}

MIYAJI, M ^{[1
]}

机构：

[1] CHIBA UNIV,DEPT EXPTL CHEMOTHERAPY,CHIBA,JAPAN

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1992年 / 29卷 / 02期

关键词：

D O I：

10.1093/jac/29.2.129

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in-vitro postantifungal effect (PAFE) of 5-fluorocytosine for Candida albicans for short periods of time was investigated. Yeast cells were exposed for 0·5,1 or 2 h to a range of concentrations (0·1-3·2 mg/L) of 5-fluorocytosine. The PAFE was quantitated by determinations of the number of colony forming units at hourly intervals (0-10 h) after removal of the drug by dilution. The length of the PAFE was dependent upon the concentration of 5-fluorocytosine and the duration of exposure. An exposure time of 0·5 h resulted in PAFE's ranging from 0 to 4·2 h. Exposure times of 1 and 2 h resulted in longer PAFEs and in many instances suppression of cell growth was seen for the entire evaluation period (up to ten hours). © 1992 by The British Society for Antimicrobial Chemotherapy.

引用

页码：129 / 136

页数：8

共 17 条

[1]

BARRIERE SL, 1990, PHARMACOTHERAPY, V10, pS134

[2] TOPICAL AND SYSTEMIC ANTIFUNGAL AGENTS [J].