AGE-RELATED-CHANGES IN ARACHIDONIC-ACID PEROXIDATION AND GLUTATHIONE-PEROXIDASE ACTIVITY IN HUMAN PLATELETS

被引：50

作者：

VERICEL, E ^{[1
]}

REY, C ^{[1
]}

CALZADA, C ^{[1
]}

HAOND, P ^{[1
]}

CHAPUY, PH ^{[1
]}

LAGARDE, M ^{[1
]}

机构：

[1] HOP CHARPENNES, SERV GERIATR, VILLEURBANNE, FRANCE

来源：

PROSTAGLANDINS & OTHER LIPID MEDIATORS | 1992年 / 43卷 / 01期

关键词：

D O I：

10.1016/0090-6980(92)90067-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipid peroxidation, vitamin E level and glutathione-peroxidase activity were determined in platelets from elderly (> 68 years) and young (21-43 years) people. To further assess the platelet lipid peroxidation, the metabolism of endogenous arachidonic acid in unstimulated platelets as well as that of the exogenous one were measured in the two groups. The oxygenated metabolites of arachidonic acid were enhanced in the elder population under both conditions tested. In addition, the platelet malondialdehyde content, a marker of the overall lipid peroxidation, was also found significantly increased in platelets from aged subjects. On the other hand, the platelet vitamin E level and the glutathione-peroxidase activity were significantly depressed in the elder group compared to the young one. These results suggest that the increased platelet activation observed with age could be linked to the accumulation of lipoxygenase-dependent peroxides associated with the decreased antioxidative defence of the cells, especially glutathione-peroxidase activity.

引用

页码：75 / 85

页数：11

共 37 条

[1] INTERACTIONS BETWEEN PROSTAGLANDIN PRECURSORS DURING THEIR OXYGENATION BY HUMAN-PLATELETS [J].